q-bio papers | Gist.Science

Cross-Sectional Age Comparisons Understate Individual Performance Decline in Endurance Athletes: A Within-Runner Analysis of 264,213 Boston Marathon Finishes

By analyzing a longitudinal panel of over 15,000 Boston Marathon runners, this study demonstrates that traditional cross-sectional comparisons significantly underestimate individual endurance performance decline—by approximately 50% at age 65—because they fail to account for the selective attrition of slower athletes who drop out of competition over time.

Owen R. Thornton, Wenjun Li2026-08-18

🧬 biology

Cognitive Demand Reveals Neural Alignment Underlying Twin Connectedness

This study reveals that twin "connectedness" does not stem from continuous spontaneous brain synchronization but rather from latent neural similarities that emerge as enhanced task-evoked neural alignment and behavioral resonance when cognitive or emotional systems are engaged.

Ying Wang, WeihaoZheng2026-08-18

🧬 biology

Exploring the Molecular and Biochemical Mechanisms of Aromasin in Modulating COX-2/iNOS for Alzheimer’s Disease-Associated Synaptic Dysfunction: An In Silico Drug Repurposing Study

This in silico drug repurposing study identifies Aromasin as a promising candidate for treating Alzheimer's disease-associated synaptic dysfunction by demonstrating its ability to simultaneously and stably bind to COX-2 and iNOS, thereby modulating inflammatory and oxidative pathways through favorable pharmacokinetics and thermodynamic stability.

Devesh Singh Baral, Rakesh Verma2026-08-18

🧬 biology

Garcinone E suppressed nasopharyngeal carcinoma by disrupting the endoplasmic reticulum–mitochondria–lysosome organelle network and modulating the FOXO1 signaling axis

This study demonstrates that Garcinone E effectively suppresses nasopharyngeal carcinoma by disrupting the endoplasmic reticulum–mitochondria–lysosome organelle network and activating the FOXO1 signaling axis, thereby inducing severe cellular stress and cytotoxicity.

Yiping Dai, Wenya Zhao2026-08-18

🧬 biology

Docking and Molecular Dynamics of the Natural Diterpenoid Dihydrotanshinone I in Human 15-PGDH Across Three Inhibitor-Bound Receptor Structures

This study utilizes structure-based docking and molecular dynamics simulations across three distinct 15-PGDH receptor structures to demonstrate that the natural diterpenoid dihydrotanshinone I is a reproducible and mechanistically plausible candidate for inhibiting 15-PGDH, a potential therapeutic target for age-related muscle decline.

Sabbir Ahmad Antor, Md Abu Sadat Soash, Muktadir Al Mahmud, Raphael Kabir Niloy, Md. Mainul Hossain Bakul, Gokul Chandra (…)2026-08-18

🧬 biology

NeuroLab OS: A local-first software environment for scientist-reviewed neural time-series modelling and provenance-aware simulation

NeuroLab OS is a local-first, scientist-reviewed software environment (version 0.1.1) that integrates neural time-series preprocessing, model simulation, and provenance tracking into a single traceable workflow, successfully passing technical verification tests while requiring further external validation for scientific validity.

peiman jannatipour2026-08-18

🧬 biology

Cross-Dataset Generalization of Quantitative EEG Spectral Biomarkers for Alzheimer’s Disease: A Pre-registered Two-Cohort External Validation and What Does Not Transfer

This pre-registered study demonstrates that while quantitative EEG spectral biomarkers for Alzheimer's disease achieve strong within-cohort performance, their cross-dataset generalization is highly fragile and dependent on acquisition setup, with relative measures like the theta/alpha power ratio proving more robust than absolute features against domain shifts.

Ivan Cangas2026-08-18

🧬 biology

Pathway-Centric Transcriptomic Profiling of Middle Ear Cholesteatoma Identifies Selective Dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 Pathways

This study analyzes transcriptomic data to reveal that middle ear cholesteatoma pathogenesis is driven by selective dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 pathways, which orchestrate keratinocyte hyperproliferation and bone erosion, thereby identifying precise molecular targets for novel therapeutic interventions.

Antonio Romeu, Maria-Jose Oliach, Coia Romeu2026-08-18

🧬 biology

Identification of a novel deletion variant in the feline CMAH gene and its prevalence in Norwegian Forest Cats

This study identifies a novel homozygous three-nucleotide deletion (c.1052_1054delATC) in the feline CMAH gene associated with blood type B in a Norwegian Forest Cat and reveals that this variant is present at a significant frequency in the breed's population, suggesting it contributes to feline blood type diversity.

Chihiro Nakamura, Chihiro Udagawa, Toshinori Omi2026-08-18

🧬 biology

Transcriptional Alterations in Triple-Negative Breast Cancer: Differential Expression, Functional Enrichment and Co-Expression Network Analysis of TCGA-BRCA

This study analyzes TCGA-BRCA data to reveal that triple-negative breast cancer is characterized by the coordinated downregulation of normal tissue architecture genes and upregulation of mitotic genes, suggesting a distinct transcriptional mechanism from intrinsic tumor heterogeneity, although these hub genes do not significantly predict patient survival.

Sushmithaa Chandrasekar2026-08-18

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