4047 papers
This study demonstrates that acute open-skill exercises like short tennis, particularly those involving visuomotor coordination and social interaction, enhance inhibitory control more effectively than walking, despite eliciting similar prefrontal cortex hemodynamics.
This study integrates bulk, single-cell, and spatial transcriptomics to demonstrate that a cell-cycle program score (CCPS) in early-stage lung adenocarcinoma predicts recurrence risk while correlating with an immune-engaged and immunoregulatory transcriptional context, though the findings do not yet establish clinical predictive utility or causal immune regulation.
HistAgent is a unified framework that combines a visual-omics foundation model with a spatial AI agentic module to infer, interpret, and retrieve spatial molecular information from routine H&E histology images, offering a cost-effective and generalizable alternative to expensive spatial transcriptomics while enabling traceable, question-driven biological analysis.
By analyzing a longitudinal panel of over 15,000 Boston Marathon runners, this study demonstrates that traditional cross-sectional comparisons significantly underestimate individual endurance performance decline—by approximately 50% at age 65—because they fail to account for the selective attrition of slower athletes who drop out of competition over time.
This study reveals that twin "connectedness" does not stem from continuous spontaneous brain synchronization but rather from latent neural similarities that emerge as enhanced task-evoked neural alignment and behavioral resonance when cognitive or emotional systems are engaged.
This in silico drug repurposing study identifies Aromasin as a promising candidate for treating Alzheimer's disease-associated synaptic dysfunction by demonstrating its ability to simultaneously and stably bind to COX-2 and iNOS, thereby modulating inflammatory and oxidative pathways through favorable pharmacokinetics and thermodynamic stability.
This study demonstrates that Garcinone E effectively suppresses nasopharyngeal carcinoma by disrupting the endoplasmic reticulum–mitochondria–lysosome organelle network and activating the FOXO1 signaling axis, thereby inducing severe cellular stress and cytotoxicity.
This study utilizes structure-based docking and molecular dynamics simulations across three distinct 15-PGDH receptor structures to demonstrate that the natural diterpenoid dihydrotanshinone I is a reproducible and mechanistically plausible candidate for inhibiting 15-PGDH, a potential therapeutic target for age-related muscle decline.
NeuroLab OS is a local-first, scientist-reviewed software environment (version 0.1.1) that integrates neural time-series preprocessing, model simulation, and provenance tracking into a single traceable workflow, successfully passing technical verification tests while requiring further external validation for scientific validity.
This pre-registered study demonstrates that while quantitative EEG spectral biomarkers for Alzheimer's disease achieve strong within-cohort performance, their cross-dataset generalization is highly fragile and dependent on acquisition setup, with relative measures like the theta/alpha power ratio proving more robust than absolute features against domain shifts.