4120 papers
This paper proposes a high-sensitivity surface plasmon resonance biosensor utilizing a MoO₂-coated photonic crystal fiber, which achieves a maximum wavelength sensitivity of 17,295.78 nm/RIU and successfully distinguishes six types of cancer cells through optimized structural design and numerical simulation.
This study reveals that during systemic inflammation, NLRP3 promotes neutrophil release from the bone marrow by establishing an IFN-γ-CXCR4 axis that downregulates CXCR4 expression on neutrophils, thereby overriding retention signals independently of G-CSF.
This study demonstrates that during gait perturbations, the trunk-head segment significantly amplifies its contribution to whole-body angular momentum while lower limb contributions decrease, suggesting that trunk coordination serves as a critical compensatory mechanism for maintaining stability, particularly in the frontal plane.
This bibliometric study analyzes 5,492 publications on the intersection of the tumor microenvironment and epigenetics to map global research trends, identify key contributors and emerging mechanisms like m6A, and provide a data-driven roadmap for future cancer therapy strategies.
This study demonstrates that *Akkermansia muciniphila* functions not as an isolated taxonomic marker but as a component of a reproducible microbial module and energy/carbon metabolic axis that more consistently links the gut microbiome to adiposity across humans and mice than the bacterium's abundance alone.
This paper presents an optimized CH-selective 1H–13C HSQC pulse scheme that utilizes one-bond scalar coupling evolution, cross-polarization, and PEP methodology to selectively detect 13CH signals with enhanced sensitivity while effectively suppressing interfering 13CH2 and 13CH3 signals in biomolecules.
Using single-nucleus RNA sequencing to overcome the limitations of bulk tissue analysis, this study reveals that the PI3K–AKT pathway response in dilated cardiomyopathy comprises distinct, cell-type-specific components—specifically an AKT1 upregulation restricted to cardiomyocytes and a PIK3CA increase peaking in fibroblasts—rather than a unified, validated therapeutic target.
Using pigs as a lipid-rich model, this study elucidates the specific roles of triglyceride lipolysis and phosphatidic acid in oocyte maturation and blastocyst formation, ultimately demonstrating that moderate overexpression of hormone-sensitive lipase significantly improves the cryopreservation survival rates of lipid-rich mammalian embryos.
This paper demonstrates that awareness is a lossy, selective transformation rather than a simple amplification of perception, showing that task-irrelevant visual features can remain unreportable yet still guide behavior, with the least aware individuals often performing best in detecting such changes.
This study demonstrates that major depressive disorder is characterized by a functional restructuring of the gut microbiome, where specific inflammatory and barrier-disrupting microbial networks significantly correlate with illness severity, recurrence, and suicidal behavior through neuroimmune, metabolic, and oxidative stress (NIMETOX) pathways.