4124 papers
This study demonstrates that extracellular vesicle-associated wild-type α-synuclein, but not Parkinson's disease mutants, selectively impairs retrograde axonal trafficking in recipient neurons by disrupting endosome transport.
This study characterizes the dysregulated microRNA profile of fibro-adipogenic progenitors in Duchenne muscular dystrophy patients, identifying hsa-miR-196a-5p as a novel regulator that inhibits adipogenic differentiation by suppressing key adipogenic and HOX genes.
This study demonstrates that integrating predefined image-derived descriptors with CNN attribution maps, specifically using ConvNeXt-Small's Integrated Gradients, effectively contextualizes the visual features driving high-accuracy classification of morphologically similar medicinal plant seeds.
This study demonstrates that CCR2-dependent recruitment of SPP1-expressing macrophages exacerbates noise-induced hearing loss by promoting pyroptosis and local inflammation, identifying the SPP1/CCR2 axis as a promising therapeutic target.
This study found that performance on standardized digit-comparison tasks is significantly associated with reading comprehension in Japanese schoolchildren with adequate decoding abilities, independent of general cognitive ability and decoding skills, suggesting these tasks may offer complementary insights for evaluating reading difficulties in this population.
This study reveals that 4-methylumbelliferone (4MU) exerts antitumor effects in AML U937 cells through a novel hyaluronic acid-independent mechanism involving metabolic reprogramming toward oxidative phosphorylation, downregulation of CD147 expression, and reduced MMP-2 activity.
This study demonstrates that the combined exposure of microplastics and hexavalent chromium causes significantly greater physiological damage and growth inhibition in freshwater *Scenedesmus* sp. compared to the more resilient marine *Chlorella* sp., highlighting the synergistic ecotoxicological threat of these co-contaminants and the utility of microalgae as bioindicators.
This study demonstrates that biological soil crusts and slope gradients synergistically regulate the community structure and functional differentiation of nitrogen-cycling microorganisms in alpine meadows by altering soil organic matter and ammonium nitrogen, thereby enhancing nitrification and driving distinct microbial adaptation strategies across different slope conditions.
This study establishes a humanized disease modeling platform using patient-derived iPSCs and 3D engineered skeletal muscles to demonstrate that specific gain-of-function RYR1 variants recapitulate key pathological features of RYR1-related myopathies, including altered myofiber morphology and disrupted excitation-contraction coupling, thereby providing a vital tool for precision medicine and therapeutic development.
Chronic prenatal corticosterone exposure in pregnant mice induces lasting, sex-specific neurobiological, endocrine, and behavioral alterations in offspring that are shaped by the combined effects of fetal programming and postnatal maternal care.