4124 papers
This study employs an integrative in silico analysis to demonstrate that synonymous variants in the ABCG2 and PPARA genes, previously considered functionally neutral, likely contribute to valproate resistance in epilepsy by disrupting pre-mRNA splicing, altering mRNA structure, and affecting translational kinetics.
This study reveals that *Oeosporangium elegans* achieves desiccation tolerance through a coordinated metabolic reprogramming that shifts from growth-associated pathways in the hydrated state to stress-responsive mechanisms involving redox balance, membrane dynamics, and protective strategies in the desiccated state.
This study demonstrates that α-Synuclein drives Parkinson's disease pathology by activating the Ras–PI3K/AKT/mTOR signaling pathway to disrupt neuronal lipid metabolism, a mechanism that can be therapeutically targeted by PI3K inhibition to restore lipid homeostasis and reduce toxic protein inclusions.
This study benchmarks fourteen classifiers for genomic breed assignment in cattle and sheep, revealing that while top models achieve high accuracy, classification difficulty is driven more by population structure than algorithm choice, with a critical trade-off identified between discrimination performance and probability calibration.
This study identifies the testis-specific protein LRRC37A as an essential molecular scaffold that coordinates the assembly of the IAM-PT-NE complex to ensure proper sperm head morphogenesis and male fertility, with its absence leading to severe teratozoospermia and infertility.
This study reports the isolation and molecular characterization of *Bacillus pumilus* PUMMD23 from agricultural soil in Southern India, identifying it as a GRAS-status bacterium capable of producing industrially valuable extracellular serine proteases for applications in detergents, pharmaceuticals, and food processing.
This study demonstrates that domestic dogs exhibit a flexible, left-to-right spatial-numerical association (SNA) that persists despite varying individual experiences and correlates with superior performance in difficult visual numerical discrimination tasks.
This study presents a reproducible 3D in-vitro skin wound model incorporating defined macrophage polarization and a standardized partial-thickness mechanical injury to facilitate the investigation of wound repair mechanisms and drug interventions.
This study reveals that bobsleigh athletes exhibit distinct spatio-temporal push characteristics on ice compared to land, particularly regarding higher step frequencies, reduced vertical displacement, and greater horizontal velocities, suggesting that land-based training requires specific modifications to prevent negative transfer and effectively replicate ice-specific demands.
This Geant4-based study demonstrates that the sensitization enhancement in nanoparticle-enhanced proton therapy is primarily driven by proton deceleration and increased linear energy transfer (LET) leading to direct double-strand breaks, rather than by secondary electrons or indirect chemical effects.