4124 papers
This study demonstrates that inhibiting Uqcrfs1 suppresses abnormal pulmonary artery smooth muscle cell proliferation and alleviates chronic hypoxia-induced pulmonary hypertension by reducing mitochondrial reactive oxygen species and endoplasmic reticulum stress, thereby validating Uqcrfs1 as a promising therapeutic target.
This study reveals that sympatric migratory birds at high altitudes exhibit distinct dietary preferences and gut microbiota compositions that drive species-specific metabolic adaptations, enabling *Grus nigricollis* to optimize fat storage via starch fermentation, *Tadorna ferruginea* to support diverse diets through fiber conversion, and *Anser indicus* to maintain homeostasis despite high microbial diversity.
This study identifies specific MT-ND1 variants and protective haplotypes as distinct mitochondrial signatures associated with chronic kidney disease susceptibility and resilience in an Egyptian cohort, suggesting mtDNA patterns as potential biomarkers for the condition.
This study reveals that a two-hit model combining traumatic brain injury and stress-enhanced fear learning alters postsynaptic protein homeostasis in the medial prefrontal cortex by disrupting the RNF25-mediated ubiquitination of GKAP, thereby contributing to exacerbated fear sensitization.
This study demonstrates that an enhanced differential learning strategy significantly alters the electromyographic activation patterns of hip and thigh muscles in female athletes during single-leg tasks, suggesting potential benefits for injury risk reduction programs despite the lack of direct biomechanical or clinical injury endpoints.
In trained eumenorrheic women, the menstrual cycle phase modulates central neuromuscular fatigue, with the greatest decline in voluntary activation occurring during the mid-luteal phase, while peripheral contractile fatigue remains consistent across all phases.
This study leverages whole-exome sequencing in the deeply phenotyped Fenland cohort to identify rare damaging variants in genes such as BRSK2, NID2, PC, COL8A1, and CASQ1 that influence glycaemic traits and resting energy expenditure, with the CASQ1 association notably revealing a sex- and menopause-dependent mechanism for declining metabolic health.
This study conducted in Orodo, Mbaitolu, Nigeria, reveals that artificial containers, particularly white and plastic ones, serve as significant mosquito breeding sites, suggesting that modifying container color and material could enhance integrated vector control strategies.
This study demonstrates that the fire-induced shift from pyrophytic to mesophytic tree dominance in eastern North American forests significantly alters soil fungal community structure and reduces the genomic potential for soil organic matter decay, thereby impacting soil carbon cycling.
This paper introduces QEPP, a dimension-matched hybrid quantum-classical framework for hierarchical Gene Ontology prediction that demonstrates a modest performance gain primarily attributable to increased representation width rather than quantum-specific advantages, while establishing a rigorous evaluation standard for future quantum biological models.