4124 papers
This study demonstrates that acute gravitational stress from parabolic flight rapidly reduces circulating plasmacytoid dendritic cells (pDCs) through the downregulation of trafficking mediators CXCL12 and CCL21, suggesting a potential impairment of antiviral immune surveillance during spaceflight.
This study reports the first identification, purification, and structural characterization of a non-TRP-family 5-hydroxyisourate hydrolase from *Lactiplantibacillus plantarum* L123, revealing a distinct all-α-helical fold with a putative His-Glu-His catalytic triad that expands the known diversity of uric acid catabolism enzymes.
This paper introduces a training-free, model-agnostic method called multi-prior posterior guidance that improves H&E-based gene expression predictions by leveraging cancer-specific co-expression patterns and spatial smoothness constraints at inference time, achieving significant performance gains across multiple cohorts without requiring model retraining.
This study presents the first genetic characterization of *Acartia tonsa* in the Caribbean using mitochondrial cytochrome b sequences, revealing shared lineages between Puerto Rican and Rhode Island populations that suggest connectivity across the western Atlantic facilitated by ocean currents like the Gulf Stream.
This study identifies a protective mechanism in ARDS recovery where the respiratory bacterium *N. resinovorum* (order Sphingomonadales) utilizes the enzyme PhhA to catabolize phenylalanine, thereby preserving alveolar macrophages and reducing lung injury, a process validated as both necessary and sufficient for therapeutic benefit.
This study demonstrates that alcohol exposure during the peri-conceptional period in mice disrupts placental development across gestation by impairing vascularization, perfusion, and mitochondrial function through altered extracellular matrix remodeling, thereby identifying placental dysfunction as a critical mechanism in Fetal Alcohol Spectrum Disorder.
This study documents the floristic diversity and functional traits of 452 plant species in Cuddalore's coastal dunes, highlighting a therophanerophytic life-form spectrum indicative of environmental heterogeneity, while identifying significant conservation challenges including endemic species, threatened flora, and a substantial invasive presence that necessitates urgent management strategies.
This paper presents a receptor-informed sparse autoencoder framework that integrates molecular structures, olfactory receptor docking profiles, and human perceptual descriptors to identify interpretable, low-dimensional latent odor concepts reflecting combinatorial coding across distributed receptor ensembles.
This study characterizes the lysine-forming saccharopine dehydrogenase (LYS1) from various filamentous fungi compared to *Saccharomyces cerevisiae*, revealing conserved structural features but distinct kinetic and thermodynamic properties that are linked to specific molecular dynamics and conformational sampling patterns.
This study demonstrates that GLG1, a gene enriched in cancer-associated fibroblasts and upregulated by tumor-derived TGF-β1/Smad2/3 signaling, promotes bladder cancer progression by enhancing cell viability, migration, invasion, and in vivo tumor growth through reinforced tumor-stromal crosstalk.