🧬 Category

q-bio

4120 papers

🧬 biology

In vivo molecular malacological screening of specific uptake of commonly used radiopharmaceuticals in the leopard slug (Limax maximus) PET/SPECT imaging to determine effectiveness and human homology

This study demonstrates that the leopard slug (*Limax maximus*) is a promising ethically favorable alternative model for molecular imaging research, as PET/SPECT analysis revealed distinct and comparable biodistribution patterns of eight common radiopharmaceuticals in its organs relative to established vertebrate data.

Joep T. van de Sanden, Bela-Simon Paschold, Damiano Librizzi, Monique R. Bernsen, Anja Taubert, Carlos Hermosilla, Frede (…)2026-08-15
🧬 biology

Usefulness of Bioelectrical Impedance Analysis in Macaques: Impact of Sedatives and Potential as Pathophysiological and Aging Indicators

This study establishes Bioelectrical Impedance Analysis (BIA) as a reliable, non-invasive tool for monitoring physiological and pathological states in macaques, demonstrating its robustness against specific anesthetic protocols and its ability to reflect age-related trends and disease conditions similar to those observed in humans.

Shunya Nakayama, Shinsuke Uchida, Yuto Sawada, Shuri Okuda, Sakura Asaoka, Ibuki Yoneda, Akihisa Kaneko, Takako Miyabe-N (…)2026-08-15
🧬 biology

Source leaves and CRF2 coordinate systemic nitrate responses in Arabidopsis

This study demonstrates that source leaves in *Arabidopsis* are essential for decoding systemic nitrogen demand via the transcription factor CRF2, which integrates root nitrate availability with shoot cytokinin signaling to sustain nitrate acquisition, root biomass allocation, and shoot metabolic homeostasis.

Sandrine Ruffel, Protto Virginia, Cannelle Armengaud, Arthur Poitout, Jeanne Rotrou, Fanchon Divol, Esther Izquierdo, Th (…)2026-08-15
🧬 biology

Genetic divergence and microbiome differentiation between bisexual and parthenogenetic populations of Haemaphysalis longicornis in Shandong, China

This study reveals that reproductive mode drives significant genetic and microbiome divergence in *Haemaphysalis longicornis* in Shandong, China, where parthenogenetic populations in coastal regions exhibit reduced genetic diversity and a specialized *Coxiella*-dominated microbiome, while bisexual populations in inland areas maintain higher genetic diversity and a more complex, diverse microbial community.

Hang-Li Su, Zhao-An Sheng, Shi-Yao Ding, Zhi-Tao Wang, Lian-Qi Yu, Can-Can Bu, Wen-Xiang Lv, Peng Cheng, Li-Juan Liu, Yu (…)2026-08-15
🧬 biology

Palmitoylation remodels the metastatic niche and drives basal-to-luminal progenitor transition in breast cancer

This study reveals that targeting palmitoylation, particularly via the inhibitor 2BP, remodels the breast cancer metastatic microenvironment by reprogramming anti-tumor immunity and driving a basal-to-luminal progenitor transition, offering a promising therapeutic strategy for liver and brain metastases.

Fuxin Huang, Wei Zhang, Peishan Dai, Bingfeng Chen, Yingyue Luo, Jingyi Wang, Shuai Liu, Zhijian Cen, Shanzhou Huang, Yu (…)2026-08-15
🧬 biology

Site-specific N6-methyladenosine fine tunes CTCF/cohesin-defined enhancer-promoter interactions and oncogenic transcription program

This study reveals that site-specific N6-methyladenosine (m6A) modification on the HOTTIP lncRNA regulates chromatin architecture and oncogenic transcription in acute myeloid leukemia by modulating RNA-dependent CTCF/cohesin function and enhancer-promoter interactions.

Suming Huang, Huacheng Luo, Karina Hamamoto, Jingwen Song, Tsz Kan Fung, Songtao He, Julia Lesperance, Ying Li, Mingjian (…)2026-08-14
🧬 biology

Rapid regulation of plasmacytoid dendritic cells after gravitational changes in parabolic flight

This study demonstrates that acute gravitational stress from parabolic flight rapidly reduces circulating plasmacytoid dendritic cells (pDCs) through the downregulation of trafficking mediators CXCL12 and CCL21, suggesting a potential impairment of antiviral immune surveillance during spaceflight.

Madlen Okkasian, Fabian Nienhaus, Alexander Lang, Stephan Binnebößel, Camila Zöhner, Christin Elster, Susanne Pfeiler, L (…)2026-08-14
🧬 biology

Recombinant Expression, Purification, and In Silico Structural Discovery of a Non-TRP-family 5-Hydroxyisourate Hydrolase from Lactiplantibacillus plantarum L123

This study reports the first identification, purification, and structural characterization of a non-TRP-family 5-hydroxyisourate hydrolase from *Lactiplantibacillus plantarum* L123, revealing a distinct all-α-helical fold with a putative His-Glu-His catalytic triad that expands the known diversity of uric acid catabolism enzymes.

Chu-Xuan Chen, Qing-Ling Wu, Yi-Ning He, Lu Liu, Kai Ding, En-Hui Zuo, Lu Yan, Cheng-Hua Wang2026-08-14
🧬 biology

Training-Free Correction of Gene Expression Predictions Using Cancer-Specific and Spatial Priors

This paper introduces a training-free, model-agnostic method called multi-prior posterior guidance that improves H&E-based gene expression predictions by leveraging cancer-specific co-expression patterns and spatial smoothness constraints at inference time, achieving significant performance gains across multiple cohorts without requiring model retraining.

Tae Joon Jun, Young-Hak Kim, Yunha Kim, Gaeun Kee, Yoobin Park, Bokyung Ahn, Chang Ohk Sung2026-08-14
🧬 biology

Phylogeographic Relationships of Acartia tonsa populations from the Western Atlantic and the Caribbean

This study presents the first genetic characterization of *Acartia tonsa* in the Caribbean using mitochondrial cytochrome b sequences, revealing shared lineages between Puerto Rican and Rhode Island populations that suggest connectivity across the western Atlantic facilitated by ocean currents like the Gulf Stream.

Martha L Ricaurte, Mónica Alfaro, Nikolaos V. Schizas, Juan G. González2026-08-14