🧬 biology

Unifying Disjoint Phenotypic Contexts: A Multimodal Soft Contrastive Approach to Identify DILI Activity Cliffs

The paper introduces BioX\mathcal{X}Mol, a multimodal framework that unifies disjoint phenotypic datasets with molecular structures using a soft contrastive objective to overcome the limitations of traditional methods and significantly improve the identification of drug-induced liver injury (DILI) activity cliffs.

Muhammad Arslan Masood, Tianyu Cui, Markus Heinonen, Samuel Kaski2026-08-18
🧬 biology

ARMOR (Antibiotic Resistance Modelling through Omics and Resistance-gene analysis)

ARMOR is an open-source machine learning pipeline that rapidly predicts *Klebsiella pneumoniae* resistance to four critical antibiotics directly from whole-genome sequencing data by leveraging biologically meaningful features like gene presence, protein k-mers, and SNPs, achieving high accuracy (AUC up to 0.986) to overcome the delays of traditional culture-based testing.

Akhyar Ahmad, Muhammad Anas, Muzammil Saleem2026-08-18
🧬 biology

Normalized Isometry Index as a bounded force-velocity metric for assessing mechanical stimulus in isometric and low-velocity muscle contractions

This paper introduces and validates the Normalized Isometry Index as a stable, bounded, and physiologically relevant metric for assessing mechanical stimulus in musculoskeletal modeling during isometric and low-velocity muscle contractions, effectively overcoming the limitations of existing force-velocity measures in near-isometric conditions.

Dobrochna Fryc2026-08-17
🧬 biology

The central thalamus tracks attentional fluctuations in humans

This study provides direct human evidence that the central thalamus tracks moment-to-moment fluctuations in sustained attention, as intracranial recordings show that larger thalamic event-related potential amplitudes predict faster reaction times and decline with time-on-task, paralleling behavioral slowing.

George Ibrahim, Sebastian Coleman, Karim Mithani, Nebras Warsi, Simeon Wong, Suna Jung, Natalie Rhodes, Vicki Li, Margot (…)2026-08-15
🧬 biology

Caffeine differently affects sleepiness and sleep physiology in rested versus sleep-restricted adolescents.

This study demonstrates that while caffeine effectively reduces subjective sleepiness in sleep-restricted adolescents, it significantly disrupts deep sleep intensity and sleep architecture, particularly during nights with adequate sleep duration, suggesting its negative physiological effects are more pronounced and less recognized when adolescents are well-rested.

Carolin Reichert, Noëmi Capdevila, Lina Lane, Hans-Peter Landolt, Christian Cajochen2026-08-15