4120 papers
This study demonstrates that Garcinone E effectively suppresses nasopharyngeal carcinoma by disrupting the endoplasmic reticulum–mitochondria–lysosome organelle network and activating the FOXO1 signaling axis, thereby inducing severe cellular stress and cytotoxicity.
This study utilizes structure-based docking and molecular dynamics simulations across three distinct 15-PGDH receptor structures to demonstrate that the natural diterpenoid dihydrotanshinone I is a reproducible and mechanistically plausible candidate for inhibiting 15-PGDH, a potential therapeutic target for age-related muscle decline.
NeuroLab OS is a local-first, scientist-reviewed software environment (version 0.1.1) that integrates neural time-series preprocessing, model simulation, and provenance tracking into a single traceable workflow, successfully passing technical verification tests while requiring further external validation for scientific validity.
This pre-registered study demonstrates that while quantitative EEG spectral biomarkers for Alzheimer's disease achieve strong within-cohort performance, their cross-dataset generalization is highly fragile and dependent on acquisition setup, with relative measures like the theta/alpha power ratio proving more robust than absolute features against domain shifts.
This study analyzes transcriptomic data to reveal that middle ear cholesteatoma pathogenesis is driven by selective dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 pathways, which orchestrate keratinocyte hyperproliferation and bone erosion, thereby identifying precise molecular targets for novel therapeutic interventions.
This study identifies a novel homozygous three-nucleotide deletion (c.1052_1054delATC) in the feline CMAH gene associated with blood type B in a Norwegian Forest Cat and reveals that this variant is present at a significant frequency in the breed's population, suggesting it contributes to feline blood type diversity.
This study analyzes TCGA-BRCA data to reveal that triple-negative breast cancer is characterized by the coordinated downregulation of normal tissue architecture genes and upregulation of mitotic genes, suggesting a distinct transcriptional mechanism from intrinsic tumor heterogeneity, although these hub genes do not significantly predict patient survival.
This study demonstrates that larger wild boar groups exhibit greater feeding persistence at carcasses while intermediate-sized groups show the highest probability of transitioning from feeding to social interaction, highlighting how group size and social dynamics drive scavenging behavior and carcass depletion.
This study evaluates solar-powered, LoRaWAN-enabled GPS ear tags on collared peccaries in southern Texas, finding that while they offer a low-cost telemetry option, their moderate fix success, positional error, and reliance on solar recharge are significantly limited by dense woody cover and species behavior, necessitating careful pilot testing before large-scale deployment.
This study reveals that selective constraint on the jawed vertebrate-specific node of Ranvier gene GLDN is highly heterogeneous, varying significantly between its olfactomedin and collagen-like domains, between mammalian and non-mammalian lineages, and across evolutionary time, patterns that would remain undetected by a single gene-wide dN/dS analysis.