Long Non-Coding RNA XIST and TSIX Modulate TGF-β-Mediated Cellular Transdifferentiation and Fibrosis in Systemic Sclerosis
This study demonstrates that the long non-coding RNAs XIST and TSIX are upregulated in systemic sclerosis, where they act as upstream regulators of TGF-β-mediated fibrosis, suggesting their potential as disease biomarkers and therapeutic targets.