4127 papers
This study demonstrates that the long non-coding RNAs XIST and TSIX are upregulated in systemic sclerosis, where they act as upstream regulators of TGF-β-mediated fibrosis, suggesting their potential as disease biomarkers and therapeutic targets.
This study presents a supervised learning framework utilizing Random Forest models with RDKit descriptors to effectively predict the bioactivity of small-molecule modulators against protein-protein interactions, achieving strong performance on internal and blind datasets while highlighting the challenges of generalizing to structurally diverse external compounds.
This study presents a hybrid computational framework combining Gated Attention Multiple Instance Learning with a reaction-diffusion model to demonstrate that oscillatory modulation of extracellular pH significantly enhances simulated therapeutic response and tumor burden reduction in breast cancer compared to chemotherapy alone.
This paper presents a modular, version-controlled, and fully reproducible end-to-end RNA-seq workflow that integrates tools from raw data processing to pathway enrichment, demonstrating its utility through a breast-cancer case study that reveals how ESR1 mutations and BET inhibitor treatment drive reciprocal transcriptional changes in key biological pathways.
This paper proposes a neuro-semantic radiogenomic framework that translates multiparametric MRI features into interpretable, evidence-linked token sequences to model glioblastoma characteristics, achieving high predictive accuracy for MGMT promoter methylation status while bridging the gap between quantitative imaging data and verifiable biomedical reasoning.
This study demonstrates that amyotrophic lateral sclerosis (ALS) is characterized by the coordinated reactivation of embryonic cytoskeletal remodeling programs, specifically involving upregulated Arp2/3-mediated actin dynamics, MYH10-associated contractility, and developmental glial pathways, suggesting these silenced mechanisms are key to disease pathogenesis and potential therapeutic targets.
This study identifies seven novel, selective human HDAC6 inhibitors through computational screening and experimental validation, revealing their unique zinc-coordinating binding mechanisms and demonstrating their potential for cross-kingdom targeting of plant tubulin deacetylases.
This integrated pan-cancer multi-omics study reveals that TMEM45A is frequently overexpressed due to DNA hypomethylation, correlates with poor prognosis and an immune-excluded tumor microenvironment, and serves as a potential biomarker for predicting sensitivity to vorinostat and resistance to docetaxel.
This study identifies a rare heterozygous *DHTKD1* exon deletion as a potential cause of sporadic cerebellar ataxia and, through a systematic review of existing cases, suggests that *DHTKD1* variants can lead to diverse neurodegenerative phenotypes via common dominant mechanisms.
This study conducted in Kano State, Nigeria, found that among type 2 diabetic patients, the haptoglobin Hp2-2 genotype is significantly associated with an increased risk of microalbuminuria, whereas the Hp1-1 and Hp2-1 genotypes are not.