4127 papers
This study demonstrates that the host gut microbiome significantly influences schistosomiasis outcomes by modulating immune responses and pathology, identifying specific bacterial biomarkers and metabolic pathways that link microbial composition to infection severity and liver fibrosis.
By integrating multi-omic data with explainable machine learning to prioritize genes based on genomic architecture rather than transcriptomic expression changes, this study overcomes the limitations of traditional screens and identifies eleven novel therapeutic targets for ALS, including ATP1A1, YWHAG, and ANLN.
This study demonstrates that methylated Actinomycin D (mAct D) exerts potent antitumor effects on human breast cancer cells by inducing endoplasmic reticulum stress and triggering caspase-dependent apoptosis through the downregulation of Bcl-2 and activation of Caspase-3/9.
This study identifies the first domestic G4P[2] Group C Rotavirus outbreak in a university setting, confirming its etiology through PCR and whole-genome sequencing while demonstrating the utility of this combined approach for precise outbreak tracing and molecular epidemiology.
This study utilizes long-read RNA sequencing combined with absolute quantification and sex-specific analysis to map high-resolution temporal transcriptional dynamics in single Mediterranean fruit fly embryos, revealing novel genes, developmental heterogeneity, zygotic genome activation waves, and early dosage compensation mechanisms.
This study demonstrates that pasteurized *Akkermansia muciniphila* alleviates obesity not by colonizing the gut, but by reshaping the microbiota to enrich *Faecalibaculum rodentium*, thereby boosting microbial arginine synthesis which activates the host NO–AMPK signaling axis to rebalance lipid metabolism.
By integrating global soil metagenomes with standardized tea-bag decomposition assays, this study reveals that ecosystem-specific litter decay rates are driven not by the presence of unique genes, but by the stage-specific abundance and variation of shared carbohydrate-active enzymes, offering a refined genomic framework for carbon-cycle modeling within defined environmental limits.
This study presents a chromosome-scale genome and transcriptome of the twig-girdler beetle *Oncideres impluviata*, revealing that clustered genomic architectures, including tandem gene arrays and multi-family superloci, facilitate the coordinated expression of chemosensory, detoxification, and digestive functions essential for host adaptation and complex plant-manipulation behaviors.
This study confirms the presence and functionality of the RNA interference machinery in *Ampelomyces* mycoparasites and their plant pathogenic relatives through genomic analysis and Spray-Induced Gene Silencing experiments, offering new insights into their evolutionary relationships and potential as biocontrol agents.
This study demonstrates that a high-fat diet induces insulin resistance in mouse skeletal muscle by increasing laminin deposition and reducing ILK-Rac1 signaling, while voluntary exercise mitigates these effects by lowering excessive laminin levels.