4127 papers
This study reveals that the deubiquitinase USP3 promotes anoikis resistance and metastasis in non-small cell lung cancer by deubiquitinating and stabilizing DNMT1, which subsequently upregulates TGF-β1 expression.
This study reveals that KIDINS220 acts as a dual-functional regulator of the phosphate exporter XPR1 by stabilizing an inactive conformation through structural rearrangements and allosteric mechanisms, thereby functioning as both a trafficking chaperone and a membrane-localized brake to precisely control cellular phosphate homeostasis.
This study demonstrates that CRB2-dependent adhesion and polarity in cortical neural progenitors, rather than in ependymal cells, are essential for maintaining ventricular wall integrity and preventing hydrocephalus by preventing lining detachment and excessive CSF permeability.
This study presents the first complete mitochondrial genome of the endangered medicinal plant *Neopicrorhiza scrophulariiflora*, revealing its multi-chromosomal structure, specific codon usage and RNA editing patterns, extensive inter-organellar DNA transfer, and phylogenetic placement within Plantaginaceae, while identifying candidate genes under positive selection that may facilitate high-altitude adaptation.
This study demonstrates that targeted mechanical unloading disrupts the mechanoflammatory feed-forward loop and restores the SOX9/RUNX2 transcriptional balance in IL-1β-sensitized murine chondrocytes, thereby attenuating catabolic responses and providing a cellular rationale for the efficacy of joint offloading procedures.
This study demonstrates that neonatal BCG inoculation induces sustained epigenetic reprogramming in porcine monocytes, characterized by widespread chromatin accessibility remodeling and enhanced transcriptional responsiveness to secondary stimulation, thereby establishing the pig as a valuable translational model for understanding BCG-mediated trained immunity.
This study reveals that Dengue virus rapidly reprograms human neutrophils to express a proinflammatory transcriptional signature characterized by key cytokine mediators, which correlates with acute patient profiles and suggests a critical role for neutrophils in driving the cytokine storm associated with severe dengue immunopathology.
Genetic deletion of SARM1 in type 2 diabetic db/db mice preferentially protects against autonomic neuropathy while also attenuating somatic nerve damage by preserving mitochondrial integrity and function.
This study utilizes an improved genome assembly of *Rhizophagus clarus* to reveal that arbuscular mycorrhizal fungi maintain non-tandemly distributed rDNA copies with heterogeneous evolutionary patterns, where most regions are more conserved within species than between them, challenging the uniformity of concerted evolution and highlighting limitations in using rDNA markers for species identification.
This systematic review and meta-analysis of 40 studies reveals that while pooled fear recognition accuracy in healthy adults is highly variable and largely driven by methodological differences in response options, the consistent confusion between fear and surprise across cultures suggests it may serve as a valuable differential indicator for future standardized clinical assessment.