4127 papers
This study demonstrates that pathological high-frequency oscillations (HFOs) are a novel biomarker of network hyperexcitability in a mouse model of dementia with Lewy bodies (DLB), exhibiting distinct characteristics and generation mechanisms compared to those in a channelopathy-induced epilepsy model.
This paper introduces a leakage-controlled evaluation framework demonstrating that frozen, ontology-grounded semantic representations of single-cell clusters consistently outperform gene-name embeddings across external datasets, whereas unconstrained LLM-generated interpretations and post hoc tuning fail to provide robust value once methodological biases are eliminated.
This study integrates bulk and single-cell RNA sequencing to reveal that glycolytic reprogramming drives intervertebral disc degeneration through cellular heterogeneity, identifying FOS and CEBPB as key upregulated regulatory genes that serve as promising diagnostic biomarkers and therapeutic targets.
This study introduces the Pharmacological Annotation Diagnostic Key (PADK), a reproducible integrative framework that successfully authenticates the morphologically convergent medicinal species *Ageratum conyzoides* and *Conoclinium coelestinum* by converging evidence from morphology, anatomy, chemotaxonomy, and literature-derived pharmacological profiles.
This study demonstrates that polyethylene biofilms in wastewater influent act as source-dependent interfaces that selectively restructure microbial communities and resistomes rather than serving as universal hotspots for antibiotic resistance gene accumulation, necessitating a multidimensional approach to risk assessment.
This study demonstrates that an ethanol extract of *Ocimum basilicum* var. *purpureum*, rich in caffeic acid-derived polyphenols, potentiates ampicillin activity against *Escherichia coli* by disrupting bacterial bioenergetics (proton flux and ATPase activity) and modulating oxidative stress responses, rather than acting as a direct antibacterial agent.
This study identifies the bZIP transcription factor SiFEA4 as a key regulator of foxtail millet panicle architecture, demonstrating that a promoter deletion in the WY159 landrace and CRISPR/Cas9-mediated knockout both lead to downregulation of the gene, resulting in abnormal inflorescence meristem differentiation, panicle apex branching, and altered plant traits through the modulation of hormone signaling pathways and direct regulation of downstream target genes.
This study demonstrates that combining gallic acid and artesunate effectively modulates the Nrf2-HO1 antioxidant and NF-κB inflammatory pathways in the liver and spleen of *Plasmodium berghei*-infected mice, with the spleen exhibiting a more dynamic and coordinated response that highlights the combination's potential as an immunomodulatory malaria therapy.
This study integrates transancestral transcriptome-wide association studies with NMN-informed pathways to identify CPT2-linked fatty-acid oxidation and MAP2K1/MAPK3 signaling as key, ancestry-specific genetic drivers of type 2 diabetes, thereby establishing a translational bridge between NAD+ precursor biology and human disease genetics.
This study reveals that anti-apoptotic Bcl-2 suppresses mitochondrial Ca2+ overload in non-apoptotic cells by directly limiting the number of ER-mitochondrial contact sites at optimal distances (10–20 nm) in an IP3R-dependent manner, thereby enhancing mitochondrial respiration without inducing cell death.