4127 papers
This study demonstrates that fecal cortisol concentrations in captive ocelots and margays in the humid tropics of Mexico remain stable for up to 24 hours post-defecation, validating fecal cortisol as a reliable biomarker for assessing stress in these Neotropical felids under such environmental conditions.
This study utilizes two longitudinal brain imaging datasets to demonstrate that pregnancy induces a transient, multi-system aging process in the maternal brain, which is followed by a postpartum rejuvenation that results in a brain age younger than pre-conception levels by 16 months.
This study presents a rigorous, leakage-free machine-learning framework using the DARWIN handwriting dataset that demonstrates handwriting dynamics contain meaningful information for Alzheimer's disease classification, achieving high performance with Random Forest (88.11% accuracy) while addressing previous concerns regarding overfitting and validation design.
This study demonstrates that the dietary diversity of six sympatric *Oxyrhopus* false coral snakes in Brazil is shaped by the combined effects of interspecific trophic differentiation, ontogenetic shifts from lizards to mammals and birds, and morphological constraints linking head width to prey size.
This study identifies the conserved decapping activator Pat1 as the critical molecular link that coordinates mRNA decay with ribosome-associated quality control by remaining on stalled mRNPs to facilitate RQT-mediated ribosome remodeling and efficient nascent peptide degradation.
This study integrates single-cell and bulk transcriptomic analyses to reveal that oxidative stress drives impaired erythroid differentiation and altered intercellular communication in β-thalassemia, identifying HSP90AA1 as a conserved, stress-responsive candidate gene linked to disrupted erythroid maturation.
This study on the Lesser Treefrog (*Dendropsophus minutus*) reveals that seasonal climate drives a temporal response hierarchy in hepatic plasticity, where whole-organism energy balance and tissue architecture respond immediately while intracellular processes lag by three months, demonstrating that the direction of biological cascades depends on the nature of the environmental driver.
This study integrates bulk transcriptomic analysis with experimental validation to identify CRNN, SMN1, and UPK1B as key RNA modification-associated genes that are significantly downregulated in allergic rhinitis, offering new insights into their roles in translation regulation and immune modulation for potential diagnostic and therapeutic applications.
This study utilized whole genome sequencing of feline sarcomatoid renal carcinoma (OBKI) cells to identify five critical genes associated with the disease, with the TSC2 gene showing the highest loss-of-function impact, thereby advancing the genetic understanding of feline kidney cancer to support future diagnostic and therapeutic developments.
This study utilizes multi-omics integrative analysis to elucidate the molecular regulatory network underlying non-pathological fetal overgrowth in Holstein IVP calves, identifying two core ceRNA regulatory axes and arginine-proline metabolism as the central pathway driving systemic physiological and biochemical changes.