4127 papers
This paper proposes a noncommutative geometric framework using quaternionic frame transport to capture protein deformation histories, enabling the distinction between ordered perturbation sequences that yield similar endpoint conformations but retain distinct internal transport memories.
This study is the first to demonstrate that sex-linked placental DNA methylation on X and Y chromosomes is significantly associated with early-onset preeclampsia, revealing critical pathological insights that were previously overlooked due to the routine exclusion of sex chromosomes in research.
Using a mouse model of maternal influenza infection, this study demonstrates that prenatal viral exposure disrupts sex-specific adolescent brain maturation trajectories and inter-regional coordination, leading to long-term sensorimotor gating deficits despite partial structural recovery by late adolescence.
This study elucidates that the PI3K/Akt/mTOR–autophagy axis in human osteoblast differentiation is predominantly regulated at the post-translational level via ribosomal protein hubs, and demonstrates that *Eupolyphaga sinensis* constituents promote fracture healing by polypharmacologically targeting and suppressing this pathway to modulate autophagy.
This study demonstrates through a biophysically detailed spiking model that adult neurogenesis enhances pattern separation and increases population sparsity beyond the dentate gyrus into the CA3 region by leveraging known DG–CA3 microcircuitry, particularly through the recruitment of inhibitory interneurons by immature granule cells.
This study demonstrates that a single 10-minute session of the Mind-Body Relaxation and Rejuvenation Technique (MBRRT) induces measurable neurophysiological changes, including increased theta, alpha, and beta EEG power, alongside significant reductions in heart rate and blood pressure, resulting in enhanced subjective feelings of relaxation and rejuvenation among healthy participants.
Whole-genome resequencing of *Posidonia oceanica* in the Western Mediterranean reveals that despite limited contemporary gene flow, the species maintains exceptional genome-wide heterozygosity and weak genetic structure through the long-term persistence of highly heterozygous, ancient clones.
This study demonstrates that for modeling juvenile green turtle abundance in southern Brazil, the Negative Binomial distribution combined with Thin Plate Regression Splines yields the most robust Generalized Additive Model by effectively addressing overdispersion and capturing complex spatial-seasonal patterns.
Repeated oral exposure to citronellol induces anxiety-like behaviors and memory deficits in mice by activating a glucocorticoid-mediated kynurenine pathway that disrupts glutamate homeostasis and causes region-specific AMPA receptor remodeling, ultimately leading to neurotoxicity via an excitotoxic mechanism.
This study identifies DTYMK as a critical oncogenic driver in glioblastoma that promotes tumor progression and mesenchymal transition by functioning as a competing endogenous RNA to sequester miR-7-5p, thereby upregulating RAF1 and activating the MAPK signaling pathway.