q-bio papers | Gist.Science

Integrated gut microbiome and cross-tissue metabolomic profiling of the gut–spleen–brain axis identifies tryptophan-related networks associated with depressive-like behaviors in a mouse model of chronic restraint stress

This study demonstrates that chronic restraint stress in mice induces gut microbial dysbiosis and coordinated, tissue-specific alterations in tryptophan metabolism across the gut-spleen-brain axis, which are significantly linked to the development of depressive-like behaviors.

Qiang Mao, Junliang Pu, Fengli Deng, Chanjuan Zhou, Zhijun Xiao, Yi Li, Chenggang Li, Haoqiang Wang, YiZhun Zhu, Rongron (…)2026-08-13

🧬 biology

Gestational benzophenone-3 exposure induces litter-dependent ovarian proteomic reprogramming linking reduced fatty acid β-oxidation to impaired ovulatory responsiveness

Maternal gestational exposure to benzophenone-3 induces litter-specific ovarian proteomic reprogramming in female offspring, where second-litter ovaries exhibit a metabolically vulnerable profile characterized by reduced fatty acid β-oxidation and mitochondrial dysfunction that likely underlies their subsequent impaired ovulatory responsiveness.

Galliani Valentina, Chávez Nube, Arias Diego, Abud Julián, Horacio Adolfo Rodríguez2026-08-13

🧬 biology

AR-Induced RP11-893F2.9 Drives Glutamine-Fatty Acid Metabolic Reprogramming and Malignant Behaviors in ccRCC

This study reveals that the androgen receptor-induced lncRNA RP11-893F2.9 drives clear cell renal cell carcinoma progression by activating the HNRNPK/TMEM92/YAP1/GLUL axis to reprogram glutamine-fatty acid metabolism and promote malignant behaviors.

Ruiming Li, Chunming Zhu, Yibing Wang, Puguang Yu, Peng Su, Hongyuan Liang, Liqun Yang, Dan Dong, Kefeng Wang2026-08-13

🧬 biology

A single early-life herbivory event increases nodule investment in African savanna woody legumes

This study demonstrates that a single early-life herbivory event significantly increases nodule biomass and allocation in African savanna woody legumes, particularly in *Vachellia sieberiana*, suggesting that young saplings adapt to browsing pressure by prioritizing nitrogen-fixing mutualisms.

Elizabeth Telford, Nicola Stevens, Sally Archibald, Wayne Twine, Caroline Lehmann2026-08-13

🧬 biology

Global research on Branchiopoda: A bibliometric and network analysis

This bibliometric and network analysis of 2,862 global publications from 1913 to 2026 maps the evolution of Branchiopoda research, revealing a shift from early pharmacological and bioassay studies toward contemporary themes in molecular systematics, conservation, and climate-related ecology, with the United States, China, and Belgium emerging as leading contributors.

Somia LAKHDARI, Lynda RAIS, Dahbia Derdah2026-08-13

🧬 biology

Structure-Guided Repurposing of SARS-CoV-2 Compounds Identifies Putative Inhibitors of Mpox Viral Enzymes

This study employs a structure-guided repurposing workflow to identify and prioritize specific SARS-CoV-2 antiviral candidates, such as J08_67 and J08_51, as potential inhibitors of key Mpox viral enzymes through rigorous computational docking, molecular dynamics simulations, and pharmacokinetic profiling.

Abubakar S. Abdullahi, Mathieu J.M. Tjegbe, Clovis S. Metuge, Sunday N. Okafor, Fidele Ntie-Kang2026-08-13

🧬 biology

Metabolic Transcriptional Heterogeneity in Human Microglia Across the Alzheimer's Disease Pathological Continuum: A Donor-Aware Analysis of the SEA-AD Atlas

An analysis of the SEA-AD atlas reveals that while broad metabolic transcriptional programs in human microglia are organized by cell state, they do not exhibit robust monotonic associations with regional Alzheimer's disease pathological burden across donors.

Ayma Waqar2026-08-13

🧬 biology

Lotmaria passim as an experimental model of trypanosomatid adaptation to the insect gut

This paper synthesizes evidence that *Lotmaria passim* serves as a robust experimental model for understanding trypanosomatid adaptation to the insect gut, demonstrating that membrane homeostasis, protein trafficking, and extracellular functions are more critical for host colonization than motility alone.

Qiushi Liu, Jing Lei, Xuye Yuan, Tatsuhiko Kadowaki2026-08-13

🧬 biology

Nutrient enrichment reshapes soil nematode communities across multiple scales through trait-based and abundance-based pathways

This study reveals that seven years of nutrient enrichment in alpine meadows reshapes soil nematode communities through distinct trait-based and abundance-based pathways, where balanced nitrogen and phosphorus addition uniquely mitigates diversity loss and stabilizes the food web by altering body size and abundance across trophic levels.

Hui Wang, Linxi Meng, Jinhao Ma, Xiao Ren, Yuying Wang, Yanjiang Cai, Lei Zhou, Pengfei Wu, Xue Wei2026-08-13

🧬 biology

The chaperone Clusterin participates in α-Synuclein neuropathology in Parkinson’s disease brain

This study demonstrates that Clusterin, a molecular chaperone, is upregulated and co-localized with α-Synuclein aggregates in the substantia nigra of Parkinson's disease patients, suggesting it initially acts protectively but becomes trapped in Lewy bodies as the disease progresses, thereby identifying it as a key mediator of proteostasis failure and a potential therapeutic target.

Sara Pizzi, Giovanni Zanchi, Alessandra Maria Calogero, Samanta Mazzetti, Alice Filippini, Giulia Carini, Veronica Mutti (…)2026-08-13

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