4127 papers
This study demonstrates that the CDT binary toxin of *Clostridioides difficile*, whose expression is induced by hypoxia via LuxS-dependent regulation, drives neutrophil activation and exacerbates inflammatory tissue damage in the hypoxic colonic environment characteristic of severe infections.
This systematic review of 75 single-cell RNA sequencing studies on five human oncoviruses reveals that while no universal host-gene signature exists, recurring virus-host programs involve complex immune interactions and viral transcript associations that vary by context, highlighting the need for rigorous study designs to develop reproducible biomarkers.
This study characterizes chromatin accessibility and its genetic regulation in the lactating bovine mammary gland by integrating ATAC-seq and RNA-seq data from 199 cows to identify thousands of caQTLs and eQTLs, revealing how specific transcription factors and chromatin states mechanistically modulate gene expression.
This systematic review evaluates the architectural, kinetic, and scaling principles of Multi‑Organ‑on‑a‑Chip systems to enhance preclinical drug translation, while identifying critical barriers such as material absorption, media standardization, and sensing integration that must be overcome for regulatory and clinical adoption.
This systematic review synthesizes evidence on fungal identification and cultivation, highlighting the superiority of a three-tiered diagnostic framework, the efficacy of both standardized and sustainable growth media, and critical operational challenges such as thermal artifacts and contamination.
This study utilizes high-resolution Micro-C, RNA-seq, and ATAC-seq analyses to demonstrate that chromosomal inversions (2La and 2Rbc) in *Anopheles* mosquitoes modulate 3D chromatin architecture and rewire enhancer-promoter interactions, thereby altering the expression of key immune genes involved in malaria parasite susceptibility.
This study reveals that the upregulated circLMF1 in mesenchymal glioblastoma promotes proneural-mesenchymal transition and simultaneously sensitizes glioblastoma stem cells to ferroptosis by stabilizing TFE3 to upregulate MVP and ABCC1, thereby identifying a therapeutic vulnerability for combinatorial targeting.
This study identifies the TFAP4-DPEP1 regulatory axis as a critical oncogenic driver in colorectal cancer that promotes malignant progression, including tumor growth, metastasis, EMT, and cancer stemness, thereby highlighting DPEP1 as a promising therapeutic target.
This paper presents a digitised, specimen-level database of 5,974 historical Lepidoptera records from Arthur Bott's private collection, offering valuable data on species distributions, conservation status, and phenotypic traits across the 20th century in standardized formats for global research use.
By integrating bulk and single-cell RNA sequencing data, this study developed a robust five-gene immune microenvironment-related prognostic model for bladder cancer that accurately predicts patient survival and identifies candidates likely to benefit from immunotherapy.