4131 papers
This study demonstrates that miR-5193 promotes ferroptosis and suppresses ovarian cancer progression by directly targeting and repressing the E3 ubiquitin ligase BBAP, which subsequently stabilizes PRNP by preventing its ubiquitination-mediated degradation.
This study utilizes resting-state EEG data from the MODMA dataset to demonstrate that Major Depressive Disorder is characterized by specific alterations in signal complexity and functional network topology, particularly involving reduced integration and increased segregation in frontal, parietal, temporal, and occipital regions, thereby establishing these metrics as promising objective neurophysiological biomarkers for the disorder.
This study utilizes bibliometric analysis of 845 Web of Science publications from 2014 to 2025 via ITGInsight to map the global research landscape of spider venom, identifying leading contributors and core journals while highlighting a shift toward molecular mechanisms and medical applications alongside a comprehensive review of its chemical constituents and pharmacological potential.
This study utilizes patient-derived xenograft models to demonstrate that adenylate kinase 1 (AK1) is a critical regulator of metastatic potential in primary triple-negative breast cancer by driving hypoxia-associated metabolic reprogramming and supporting tumor cell survival and migration.
By analyzing common blackbird movement in Munich and Angers, this study demonstrates that while absolute habitat resistance values vary between cities, combining data from multiple urban environments significantly improves the predictive accuracy and transferability of connectivity models for identifying relative barrier importance.
This study demonstrates that HIV-1 infection of BBB pericytes, whether active or latent, disrupts endothelial cell integrity by enhancing gap junction-mediated communication, thereby driving neuroinflammation and contributing to HIV-associated neurocognitive impairments.
This study integrates multi-omics data from nearly 1,000 donors across 17 cardiovascular tissues to characterize sex-dimorphic aging patterns, identifying high-confidence, actionable biomarkers and therapeutic targets—such as GUCY1A2 and PDE5A—that converge on specific signaling axes to advance precision cardiovascular medicine.
This study integrates computational modeling and biophysical experiments to identify the epidermal growth factor receptor (EGFR) as a primary molecular target of the anticancer lignan Cleistanthin A and its derivatives, demonstrating their strong binding affinity and stability as potential scaffolds for developing novel EGFR inhibitors.
This study demonstrates that a high-salt diet induces hypertension in salt-sensitive rats by disrupting gut microbiota, which subsequently impairs glycerophospholipid metabolism and leads to vascular dysfunction and inflammation.
This study demonstrates that habitat-adapted dark septate endophytes, specifically *Alternaria chlamydospora* SC11, stabilize the soil-root-plant continuum in *Suaeda salsa* under severe sulfate salinity by maintaining nutrient homeostasis, root integrity, and coordinated metabolic responses, whereas non-adapted isolates fail to provide these benefits.