🧬 Category

q-bio

4165 papers

🧬 biology

Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation

This study demonstrates that while insulin-derived fibrils with and without phenolic preservatives share similar structural properties, the presence of preservatives significantly enhances fibril-induced cytotoxicity and ROS production in macrophages, revealing distinct immunomodulatory mechanisms that underscore the need for strategies to improve the biocompatibility of insulin infusion devices.

Priscila Silva Cunegundes, Congxiao Cheng, Elizabeth Wisman, Daniel L. Menkes, Ulrike Klueh2026-08-13
🧬 biology

Low-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)

This study reveals that prolonged cold stress induces severe neuro-oxidative damage and metabolic reprogramming in the juvenile fourfinger threadfin brain, characterized by initial antioxidant suppression followed by late-stage failure, lipid peroxidation, and disrupted amino acid and glycerophospholipid metabolism, ultimately offering critical insights for improving cold tolerance in aquaculture.

Jing Li, Shui-Ping He, Min-Xuan Jin, Nuo Chen, An-Na Zheng, Jing-Heng Lu, Wei-Bin Liu, Lin-Juan Wang, Hui-Juan Zhang, Ba (…)2026-08-12
🧬 biology

Functional dissociation of place and spatial view codes in primate hippocampus

This study demonstrates that the primate hippocampus contains distinct, coexisting populations of position, view, and conjunctive cells, resolving the debate over species differences by showing that robust rodent-like place codes exist in primates but were previously overlooked due to methodological and task-related factors.

Inah Lee, Seuk-Hwan Shin, Heung-Yeol Lim, Su-Min Lee, Jae-Min Seol, Bona Lee, Choong Lee, Yuji Naya, Joonyeol Lee2026-08-12
🧬 biology

Mechanistic Study of Deoxyshikonin-Mediated Protection Against High-Glucose-Induced Injury in HUVECs

This study demonstrates that deoxyshikonin (3 µM) protects human umbilical vein endothelial cells from high-glucose-induced injury by restoring angiogenic capacity and modulating the expression of key downstream effectors, including IFITM1, THY1, CCBE1, CCL2, and ENTPD1, through pathways involving extracellular matrix organization, inflammation, and angiogenesis.

Chao Bai, Wenwen Yang, Xiaoyun Ni, Pengfei Xu, Tuerdebieke Jiakesileke, Shuyao Li, Tao Liu2026-08-12
🧬 biology

Overt intentions for answers Yes and No are influenced by feedback and context

This study introduces an "Akinator"-inspired experimental paradigm to demonstrate that neural signatures of binary mental agreement and disagreement, including P3a and N270 components, are significantly modulated by feedback, stimulus context, and presentation sequence, thereby advancing the development of BCI communication and verification systems.

Artemiy Berkmush-Antipova, Nikolay Syrov, Timofei Ponomarev, Lev Yakvolev, Andrei Miroshnikov, Nataliya Shusharina, Alex (…)2026-08-12
🧬 biology

Low-dimensional factorized neural computations underlie risk-adaptive choices

This study demonstrates that risk-adaptive decision-making relies on low-dimensional neural computations that segregate safe and risky states, a mechanism identified through deep reinforcement learning agents and validated by similar dynamical patterns in human neuronal recordings.

Elliot Smith, T Price, Andrew Liu, Rhiannon Cowan, Niloufar Shahdoust, Tyler Davis, Bornali Kundu, John Rolston, Shervin (…)2026-08-12
🧬 biology

EEG-Based Identification of Hidden Functional Topography Changes in Major Depressive Disorder

This study utilizes resting-state EEG data from the MODMA dataset to demonstrate that Major Depressive Disorder is characterized by specific alterations in signal complexity and functional network topology, particularly involving reduced integration and increased segregation in frontal, parietal, temporal, and occipital regions, thereby establishing these metrics as promising objective neurophysiological biomarkers for the disorder.

Divyanshi Kanwar¹, R. K. Brojen Singh², Jasleen Gund¹2026-08-12
🧬 biology

Bibliometric Analysis of Spider Venom Research Based on ITGInsight

This study utilizes bibliometric analysis of 845 Web of Science publications from 2014 to 2025 via ITGInsight to map the global research landscape of spider venom, identifying leading contributors and core journals while highlighting a shift toward molecular mechanisms and medical applications alongside a comprehensive review of its chemical constituents and pharmacological potential.

Hong Chi Ding, Fang Yang, Yan Qing Yang, Xi Liu, Jian Fang Yang, Can Wei Li, Zi Zhong Yang, Hai Rong Zhao, Yu Zhao, Wei (…)2026-08-12
🧬 biology

A Patient-Derived Xenograft Model Identifies AK1 as a Key Regulator of Metastatic Potential in Primary Triple-Negative Breast Cancer

This study utilizes patient-derived xenograft models to demonstrate that adenylate kinase 1 (AK1) is a critical regulator of metastatic potential in primary triple-negative breast cancer by driving hypoxia-associated metabolic reprogramming and supporting tumor cell survival and migration.

Jong-Il Kim, Dakyung Lee, Rokhyun Kim, Woohang Heo, Sieun Yang, Woochan Lee, Jihui Yun, Charles Lee, Sun-Wha Im, Jeesoo (…)2026-08-12