🧬 Category

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4194 papers

🧬 biology

Post-translational Regulation of the PI3K/Akt/mTOR–Autophagy Axis in Osteoblast Differentiation and Its Polypharmacological Targeting by Eupolyphaga sinensis

This study elucidates that the PI3K/Akt/mTOR–autophagy axis in human osteoblast differentiation is predominantly regulated at the post-translational level via ribosomal protein hubs, and demonstrates that *Eupolyphaga sinensis* constituents promote fracture healing by polypharmacologically targeting and suppressing this pathway to modulate autophagy.

Yingjie Wu, Yang Lv, Hegui Xu2026-08-13
🧬 biology

Adult neurogenesis promotes pattern separation and sparsity beyond the dentate gyrus in a spiking DG–CA3 model

This study demonstrates through a biophysically detailed spiking model that adult neurogenesis enhances pattern separation and increases population sparsity beyond the dentate gyrus into the CA3 region by leveraging known DG–CA3 microcircuitry, particularly through the recruitment of inhibitory interneurons by immature granule cells.

Marlon Valmórbida Cendron, Wilfredo Blanco Figuerola, Flávio Freitas Barbosa2026-08-13
🧬 biology

Neuro-physiological Study on a Mind-Body Relaxation and Rejuvenation Technique

This study demonstrates that a single 10-minute session of the Mind-Body Relaxation and Rejuvenation Technique (MBRRT) induces measurable neurophysiological changes, including increased theta, alpha, and beta EEG power, alongside significant reductions in heart rate and blood pressure, resulting in enhanced subjective feelings of relaxation and rejuvenation among healthy participants.

Anurag Jayswal, Kabita Devi, Deepeshwar Singh, Bhabesh Deka, Suvendra Kumar Ray2026-08-13
🧬 biology

Evaluation of Smoothing Functions in Generalized Additive Models Applied to the Relative Abundance of Green Turtle (Chelonia mydas)

This study demonstrates that for modeling juvenile green turtle abundance in southern Brazil, the Negative Binomial distribution combined with Thin Plate Regression Splines yields the most robust Generalized Additive Model by effectively addressing overdispersion and capturing complex spatial-seasonal patterns.

Letícia Verônica Santos, Thayana Gião, Raquel da Fontoura Nicolette, Juliano César Marangoni, Gustavo Martinez-Souza2026-08-13
🧬 biology

Disrupted Kynurenine Pathway and AMPA Receptor-Associated Neurotoxicity of Citronellol in Mice

Repeated oral exposure to citronellol induces anxiety-like behaviors and memory deficits in mice by activating a glucocorticoid-mediated kynurenine pathway that disrupts glutamate homeostasis and causes region-specific AMPA receptor remodeling, ultimately leading to neurotoxicity via an excitotoxic mechanism.

Han-Seul Lee, Dae-Seop Shin, Seong Soon Kim, Sung-Hee Cho, Myung Ae Bae, Ki-Tae Kim2026-08-13
🧬 biology

DTYMK Functions as a ceRNA to Promote Glioblastoma Progression and Mesenchymal Phenotype Through miR-7-5p/RAF1/MAPK Signaling

This study identifies DTYMK as a critical oncogenic driver in glioblastoma that promotes tumor progression and mesenchymal transition by functioning as a competing endogenous RNA to sequester miR-7-5p, thereby upregulating RAF1 and activating the MAPK signaling pathway.

Hao Yuan Wu, Zhi We Wang, Zi Wen Chen, Zhen Xing He, Chen Xi Chang, ZeJin Li, DeRan Zhang, JinRuo Zhang, ZhiHao Yang, Bi (…)2026-08-13
🧬 biology

Integrated gut microbiome and cross-tissue metabolomic profiling of the gut–spleen–brain axis identifies tryptophan-related networks associated with depressive-like behaviors in a mouse model of chronic restraint stress

This study demonstrates that chronic restraint stress in mice induces gut microbial dysbiosis and coordinated, tissue-specific alterations in tryptophan metabolism across the gut-spleen-brain axis, which are significantly linked to the development of depressive-like behaviors.

Qiang Mao, Junliang Pu, Fengli Deng, Chanjuan Zhou, Zhijun Xiao, Yi Li, Chenggang Li, Haoqiang Wang, YiZhun Zhu, Rongron (…)2026-08-13
🧬 biology

Gestational benzophenone-3 exposure induces litter-dependent ovarian proteomic reprogramming linking reduced fatty acid β-oxidation to impaired ovulatory responsiveness

Maternal gestational exposure to benzophenone-3 induces litter-specific ovarian proteomic reprogramming in female offspring, where second-litter ovaries exhibit a metabolically vulnerable profile characterized by reduced fatty acid β-oxidation and mitochondrial dysfunction that likely underlies their subsequent impaired ovulatory responsiveness.

Galliani Valentina, Chávez Nube, Arias Diego, Abud Julián, Horacio Adolfo Rodríguez2026-08-13