🧬 Category

q-bio

4194 papers

🧬 biology

Systematic Review of Microfluidic Inter-Organ Communication: Architectural Topologies, Biomolecular Transport Vectors, and Allometric Scaling in Multi‑Organ‑on‑a‑Chip Systems

This systematic review evaluates the architectural, kinetic, and scaling principles of Multi‑Organ‑on‑a‑Chip systems to enhance preclinical drug translation, while identifying critical barriers such as material absorption, media standardization, and sensing integration that must be overcome for regulatory and clinical adoption.

Shubhanshi Srivastava2026-08-13
🧬 biology

Chromosomal inversions modulate 3D chromatin interactions and regulatory architecture in Anopheles gambiae

This study utilizes high-resolution Micro-C, RNA-seq, and ATAC-seq analyses to demonstrate that chromosomal inversions (2La and 2Rbc) in *Anopheles* mosquitoes modulate 3D chromatin architecture and rewire enhancer-promoter interactions, thereby altering the expression of key immune genes involved in malaria parasite susceptibility.

Kathryn S. Taquet, Cameron E. Anderson, Kenneth D. Vernick, Michelle M. Riehle2026-08-13
🧬 biology

CircLMF1 Activates the TFE3-MVP/ABCC1 Pathway to Promote Mesenchymal Transition and Sensitize Glioblastoma to Ferroptosis

This study reveals that the upregulated circLMF1 in mesenchymal glioblastoma promotes proneural-mesenchymal transition and simultaneously sensitizes glioblastoma stem cells to ferroptosis by stabilizing TFE3 to upregulate MVP and ABCC1, thereby identifying a therapeutic vulnerability for combinatorial targeting.

Maierdan Mansuer, Peiwen Yao, Guifei Zhang, Yuzhen Xu, Liang Gao, Yang Jiang2026-08-13
🧬 biology

Integrating Multi-dimensional RNA Sequencing to Construct a Prognostic Risk Model for Bladder Cancer

By integrating bulk and single-cell RNA sequencing data, this study developed a robust five-gene immune microenvironment-related prognostic model for bladder cancer that accurately predicts patient survival and identifies candidates likely to benefit from immunotherapy.

Yabo Zhai, Zhiwen Wang, Zhouhui Chen, Yuxuan Zhang, Yihao Zhu, Xuwen Li, Jianguo Zheng, Xinghang Dai, Xinwei Wang, Kaope (…)2026-08-13
🧬 biology

Mandible shape reflects ecotypic divergence and population dynamics in an Arctic carnivore: the case of the Icelandic Arctic fox

This study demonstrates that mandible shape in Icelandic Arctic foxes exhibits significant phenotypic divergence driven by ecotypic dietary differences between coastal and inland habitats, as well as by early-life population density conditions that manifest morphologically as the animals age.

Anna Bára Másdóttir, Snæbjörn Pálsson, Nicolas Lecomte, Bruce James McAdam, Ester Rut Unnsteinsdóttir2026-08-13
🧬 biology

Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation

This study demonstrates that while insulin-derived fibrils with and without phenolic preservatives share similar structural properties, the presence of preservatives significantly enhances fibril-induced cytotoxicity and ROS production in macrophages, revealing distinct immunomodulatory mechanisms that underscore the need for strategies to improve the biocompatibility of insulin infusion devices.

Priscila Silva Cunegundes, Congxiao Cheng, Elizabeth Wisman, Daniel L. Menkes, Ulrike Klueh2026-08-13
🧬 biology

Low-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)

This study reveals that prolonged cold stress induces severe neuro-oxidative damage and metabolic reprogramming in the juvenile fourfinger threadfin brain, characterized by initial antioxidant suppression followed by late-stage failure, lipid peroxidation, and disrupted amino acid and glycerophospholipid metabolism, ultimately offering critical insights for improving cold tolerance in aquaculture.

Jing Li, Shui-Ping He, Min-Xuan Jin, Nuo Chen, An-Na Zheng, Jing-Heng Lu, Wei-Bin Liu, Lin-Juan Wang, Hui-Juan Zhang, Ba (…)2026-08-12