4194 papers
This study demonstrates that multiple native mosquito species in temperate England, particularly *Culex pipiens* s.l., play a significant role in the circulation and maintenance of Usutu virus, with phylogenetic analysis confirming the co-circulation of distinct viral lineages and suggesting that warmer weather may facilitate transmission.
This study reanalyzes peripheral blood transcriptomic data from adult tuberculous meningitis patients to identify a neutrophil–matrix metalloproteinase axis as a key pathogenic feature, thereby prioritizing doxycycline as a promising host-directed therapy for experimental validation.
This study presents a comprehensive quantitative benchmark of three specialized AI research agents (K-Dense, Finch, and Biomni) against ChatGPT for omics data interpretation, revealing that no single agent dominates all modalities and that agent architecture, rather than base-model capability, is the primary determinant of output quality and suitability for specific bioinformatic workflows.
This study demonstrates that the strong bulk-level transcriptional correlation between TREM2 and HAVCR2 in colorectal cancer is primarily driven by microsatellite instability-high (MSI-H) status rather than mucinous histology, highlighting the necessity of MSI-stratified analyses and signature de-circularization to avoid misleading associations in immune transcriptomic research.
This study characterizes the phenotypic and genomic profiles of 110 multidrug-resistant *Acinetobacter baumannii* isolates from clinical and environmental sources in Mysuru, India, revealing the universal presence of the carbapenemase gene *blaOXA-23* alongside high frequencies of *blaOXA-66* and *blaNDM-1*, which underscores the critical need for enhanced genomic surveillance and infection control measures to curb the spread of carbapenem resistance in healthcare settings.
This study demonstrates that while ALS-associated TDP-43 gain-of-function mutations do not impair muscle homeostasis, complete loss of TDP-43 in skeletal muscle stem cells triggers premature aging, stem cell depletion, and severe regenerative failure.
This study demonstrates that in *Angiostrongylus cantonensis*-induced eosinophilic meningoencephalitis, upregulated miR-155-5p targets and suppresses Sirtuin-1, thereby activating the NF-κB pathway to induce apoptosis in microglial cells.
In a 60-day head-down bed rest study simulating spaceflight, healthy men experienced a spontaneous decrease in energy intake and specific shifts in food preferences and reward, but neither exercise nor artificial gravity countermeasures significantly altered these dietary responses.
This study demonstrates that targeted deoxycholic acid-loaded nanoliposomes effectively enhance cellular uptake and reprogram tumor-associated macrophages from an immunosuppressive M2 phenotype to a pro-inflammatory M1 phenotype, offering a promising nanotherapeutic strategy for cancer immunotherapy.
This study integrates cell-type-resolved DNA methylation and heat-stress transcriptome data to identify a compact, convergent gene set distinguishing indicine and taurine cattle, offering a validated epigenetic marker set for thermotolerance and selection in tropical breeds.