q-bio papers | Gist.Science

Berberine from Coptidis Rhizoma enhances host antifungal immunity against dermatophytosis and cutaneous candidiasis via JNK signaling and autophagy

This study demonstrates that berberine, the active compound in *Coptidis Rhizoma*, combats dermatophytosis and cutaneous candidiasis through a dual mechanism of direct fungicidal and antibiofilm activity alongside the enhancement of host antifungal immunity via JNK signaling-mediated autophagy, thereby offering a promising synergistic strategy against refractory fungal infections.

Yuyuan Xue, Mingjing Wei, Xindi Ma, Yuhang Mei, Li Li, Junhao Zhu, Guo Chen, Min Zhu2026-08-12

🧬 biology

Structure-Based Phylogenomics Reveals the Evolutionary Reservoir of Plant Cysteine-Rich Peptides

This study establishes a structure-based phylogenomic framework to decode the evolutionary landscape of plant cysteine-rich peptides, revealing them as an "evolutionary reservoir" in Poaceae that drives functional innovation, as exemplified by the essential role of the newly characterized RMF1 peptide in cereal male fertility and its potential for crop improvement.

Kenan Tan, Jiajie He, Twan Rutten, Amanda Camara, Thorsten Schnurbusch2026-08-12

🧬 biology

Motor Primitives in the Wild: An ROV Study Investigating Octopus Reaching and Fetching Movements in the Natural Habitat

This study confirms that *Octopus vulgaris* utilizes the laboratory-identified motor primitives of Reaching and Fetching during natural nocturnal foraging, demonstrating that these simplified motor building blocks are fundamental to arm control in the wild.

Selina Ernst, Daniel Kalysch, Wolfgang Slany, Tamar Gutnick, Michael J. Kuba2026-08-12

🧬 biology

Attention modulates cortical and subcortical responses to auditory deviance: An EEG-pupillometry study in healthy adults

This study demonstrates that while both pupil dilation and EEG signals reflect auditory deviance processing, pupil responses remain sensitive to attentional demands even when ERP effects are significantly attenuated by visual interference.

Miguel Contreras Altamirano, Stefan Debener, Karsten Witt2026-08-12

🧬 biology

Structure-Guided Prioritization of Amphipathic Antimicrobial Peptide Candidates against ESKAPE Pathogens via Generative Design and Physicochemical Filtering

This study presents a systematic in silico pipeline combining a pathogen-conditioned generative model (BioAMPify) with multi-stage physicochemical and structural filtering to efficiently identify and prioritize 10 high-priority, non-toxic amphipathic antimicrobial peptide candidates against multidrug-resistant ESKAPE pathogens.

Zubia Rashid¹, Muhammad Razi Uddin Siddiqui, Sania Nisar2026-08-12

🧬 biology

No sign of Species-Genetic Diversity Trade-off in Pseudotsuga menziesii (Mirb.) Franco in UK Continuous Cover Forests

This study found that converting planted Douglas-fir forests to Continuous Cover Forestry in the UK does not result in a short-term trade-off between species diversity and genetic diversity, as genetic diversity remained stable between adult trees and juvenile seedlings despite variable effective population sizes.

Laura Guillardin, Glenn Howe, Ella Glover, John MacKay2026-08-12

🧬 biology

Eliglustat-Induced Remodeling of Sulfo-Glycosphingolipid Metabolism and Gene Expression in hepatocellular carcinoma cells

This study demonstrates that inhibiting UGCG with eliglustat in hepatocellular carcinoma HepG2 cells induces dose-dependent remodeling of sulfo-glycosphingolipid metabolism and triggers extensive transcriptional reprogramming characterized by stress-response activation and cell-cycle suppression, revealing both tumor-suppressive effects and adaptive metabolic compensatory mechanisms.

Rachele Giannecchini, Matteo Niero, Fabio Bozzi, Federica Padelli, Alessia Bertolotti, Antonino Belfiore, Luca Agnelli (…)2026-08-12

🧬 biology

ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar size

This study identifies that type III collagen in the fibrotic extracellular matrix activates ADGRG1–RhoA signaling in reactive astrocytes to halt their migration and form the glial scar border, and demonstrates that blocking this pathway allows astrocytes to enter the lesion, thereby reducing scar size and promoting axonal regeneration and motor recovery after spinal cord injury.

Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Kazuya Yokota, Tetuya Tamaru, Kazuhiro Hata, Hirotaka Iura, Yohei Haruta (…)2026-08-12

🧬 biology

Comparison of cortical auditory evoked potentials in anesthetized versus awake Jamaican fruit bats

This study demonstrates that while isoflurane anesthesia significantly suppresses the amplitude and sensitivity of cortical auditory evoked potentials in Jamaican fruit bats, the waveforms recorded from anesthetized subjects remain qualitatively similar to those from awake, freely moving bats, validating the use of anesthesia for preliminary auditory investigations in this species.

Sam Ellis, Victoria Fouhy, Michael Smotherman2026-08-12

🧬 biology

Integrated Analysis of Serum Non-Targeted Metabolomics and Lipidomics for Exploring the Mechanism of Lactobacillus rhamnosus in Regulating Fat Deposition in Mice

This study demonstrates that *Lactobacillus rhamnosus* supplementation significantly increases abdominal fat deposition in mice without altering body weight, a process mediated by elevated fecal short-chain fatty acids and the modulation of serum glycerophospholipid and phosphatidylinositol signaling pathways.

Caiye Zhu, Yanxin Wang, Yan Luo, Bo Gao, Qianru Hou, Yue Zhang, Xiaoyu Huang2026-08-12

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