🧬 Category

q-bio

4194 papers

🧬 biology

Assessment of genetic variance, phylogenetic relationship and population structures using multiple molecular marker systems in popular varieties of citrus

This study evaluated four molecular marker systems (RAPD, ISSR, SCoT, and CBDP) to characterize 19 popular citrus varieties, concluding that SCoT markers are the most efficient for germplasm characterization due to their superior polymorphism and PIC values, while revealing that the majority of genetic variation exists within rather than between populations.

Jagan Singh Gora, Ramesh Kumar, Pawan Kumar, Rakesh Singh, Shravan Manbhar Haldhar, Mukesh Kumar Berwal, Chet Ram, Ved P (…)2026-08-12
🧬 biology

Molecular Heterogeneity of Aging: Insights from Integrated Plasma Proteome

Through an integrative analysis of plasma proteomics and clinical blood parameters in 99 healthy individuals, this study identifies a specific eight-marker aging signature and reveals that molecular heterogeneity peaks at different life stages, highlighting significant inter-individual variability in physiological aging.

Elizaveta Sarygina, Varvara Blinova, Arina Gordeeva, Anna Kliuchnikova, Anna Kozlova, Svetlana Tarbeeva, Aziz Abdurahimo (…)2026-08-12
🧬 biology

Interpretable machine learning reveals biochar-specific hydraulic predictors of plant microbial fuel cell performance under unsaturated soil conditions

This study employs interpretable machine learning on time-resolved experimental data to demonstrate that matric suction and specific biochar amendments (particularly reed straw) are the key hydraulic and treatment-level predictors of electrical potential and power density in unsaturated soil plant microbial fuel cells.

Sibin Gan¹, Qinyue Yao²2026-08-12
🧬 biology

An adipocyte-endothelial framework linking adipose tissue inflammation to cardiometabolic vulnerability in obesity

This study establishes a cell-type-resolved framework linking obesity-induced adipose tissue inflammation to cardiometabolic vulnerability by identifying distinct molecular dysfunction in adipocytes and endothelial cells, validating their recovery after weight loss, and generating high-accuracy models to assess cardiometabolic risk.

Vaishali Chaurasiya, Luyang Li, Aina Lluch, Ana Fernández-Sánchez, Jukka Harju, Dan Duc Pham, Sanni Perttunen, Salla Kes (…)2026-08-12
🧬 biology

Activity-guided Fractionation and in Vitro Anticancer Evaluation of Bioactive Phytoconstituents From Clitoria Ternatea L. Flowers Against HT-29 Human Colorectal Cancer

This study demonstrates that activity-guided fractionation of *Clitoria ternatea* L. flowers yields an ethyl acetate fraction enriched with flavonoids and phenolics, which exhibits the most potent concentration-dependent cytotoxicity against HT-29 human colorectal cancer cells with an IC₅₀ of 79.29 µg/mL.

Arati Ravindra Kapase, Priya P. Shetti, Ansar M. Patel2026-08-12
🧬 biology

Ten-Eleven Translocation promotes muscle progenitor maintenance through cell-autonomous and niche-dependent mechanisms

This study reveals that the epigenetic regulator TET maintains *Drosophila* muscle progenitors by acting cell-autonomously to directly activate stemness genes like *zfh1* and non-cell autonomously to promote niche-derived Notch signaling via *Delta*, thereby coordinating intrinsic transcriptional programs with extrinsic signals to balance self-renewal and differentiation.

Lucas Waltzer, Vincent Gerdy, Yoan Renaud, Nadège Anglaret, Romane Bertrand, Stephanie Maupetit-Méhouas, Nicolas Allègre (…)2026-08-12
🧬 biology

Time‑varying EEG survival modeling predicts aviation crash risk in simulated flight

This study demonstrates that a proof-of-concept pipeline integrating time-varying EEG engagement indices with survival modeling and Kalman filtering can predict aviation crash risk approximately one minute before impact in a simulated helicopter environment, offering a promising framework for real-time neuroadaptive flight-deck systems.

Xiaomin Yue, Kathryn Feltman, Jonathan Vogl, Amanda Kelley2026-08-12
🧬 biology

A dual-arm peptide vaccine against KRAS, EGFR, PD-L1 and VEGFR2 for non-small cell lung cancer in Vietnamese patients

This study presents CRUISER, a computationally designed dual-arm peptide vaccine tailored to Vietnamese HLA profiles that targets KRAS, EGFR, PD-L1, and VEGFR2 to achieve superior population coverage and predicted stability compared to global alternatives, though its efficacy remains pending experimental validation.

Dung Vu Luu, Hau Nguyen Xuan, Trang Le Huyen, Giang Nguyen Huong, Trang Nguyen Ngoc, Lan Nguyen Thi Phuong, Hoang Nguyen (…)2026-08-12