4194 papers
This study integrates transcriptome meta-analysis, weighted gene co-expression network analysis, and machine learning to identify a highly predictive set of 276 conserved drought-responsive genes in peanut, providing a robust foundation for future functional validation and genomics-assisted breeding of drought-resilient cultivars.
This study demonstrates that a parameter-efficient hierarchical cascade classifier, which decomposes motor imagery into progressive difficulty levels, performs comparably to a flat multiclass model while offering a clinically superior framework for neurorehabilitation by accommodating patients' partial information and residual capabilities.
This study reveals that the splicing factor SF3B4 promotes esophageal squamous cell carcinoma growth and cisplatin resistance by driving an alternative 5′ splice site switch in the lncRNA HOXA11-AS to produce the HOX-L isoform, which activates β-catenin signaling and glycolytic reprogramming.
This study identifies a mitochondria-centered adaptive program in osimertinib-resistant EGFR-mutant NSCLC, driven by mitochondrial dysfunction and a compensatory pyruvate-acetaldehyde-acetate (PAA) metabolic bypass that sustains tumor survival and reveals ALDH2 as a potential therapeutic target to overcome drug resistance.
This study presents a curated, openly accessible spatial transcriptomic dataset of the human adrenal gland from 10 donors, generated via the 10x Genomics Visium platform and standardized reprocessing, which preserves the gland's spatial zonation to facilitate advanced computational modeling and endocrine research despite the inherent resolution limits of spot-level analysis.
Nanotransfer is a novel multi-modal computational tool that accurately detects and spatially maps rare intercellular horizontal DNA transfer events in single-cell and spatial genomics data, overcoming the limitations of standard bioinformatic pipelines that typically misclassify these transfers as noise or artifacts.
This study utilizes thick hippocampal cryosections to demonstrate that the CNS extracellular space comprises over 25% of the tissue volume, featuring a highly porous architecture with voids ranging from narrow interstitial openings to large perivascular spaces that facilitate CSF flow and cell motility.
This study reveals that the upregulated splicing factor SF3B4 promotes cisplatin resistance and metabolic reprogramming in esophageal squamous cell carcinoma by driving an alternative 5′ splice site switch in the lncRNA HOXA11-AS to generate the oncogenic HOX-L isoform, which activates β-catenin signaling and glycolysis.
This study utilizes transcriptomic analysis to identify and characterize specific peroxidase genes in *Pyropia haitanensis* that regulate hydrogen peroxide homeostasis, offering a molecular foundation for optimizing spore production techniques through future structural modeling and in vitro validation.
This study characterizes *Pseudomonas mandelii* Y02, a novel psychrotolerant Antarctic strain capable of efficiently degrading multiple herbicides as sole carbon sources and mitigating their phytotoxicity in plants, highlighting its significant potential for bioremediation in cold and temperate environments.