4194 papers
BARCODE is an interpretable, data-efficient image-to-sequence model that converts chromosome G-banding patterns into ISCN-aligned symbolic sequences to enable zero-shot structural abnormality detection and precise band-level localization without requiring training on abnormal samples.
This study identifies and validates three macrophage polarization-related genes (PTCHD1, NEURL1, and ST8SIA5) as robust diagnostic biomarkers for tendinopathy, revealing their downregulation, association with immune infiltration, involvement in key signaling pathways, and potential as therapeutic targets.
This study utilizes longitudinal multi-omic profiling to characterize the phased immune and tissue-remodeling responses of a six-gene-edited pig-to-human lung xenograft over nine days, revealing distinct molecular signatures of complement activation, myeloid remodeling, and epithelial recovery that inform future donor engineering and immunosuppressive strategies.
This study utilized an integrated computational pipeline, including molecular dynamics simulations and docking, to identify and validate three promising siRNA candidates (S3, S4, and S7) targeting the conserved hemagglutinin gene of the measles virus for potential antiviral therapeutic development.
This study reveals that perturbing specific chromatin regulators disrupts the transcriptional balance of the heme biosynthesis pathway—particularly affecting its middle enzymes while sparing the iron-regulated terminal enzyme—leading to toxic porphyrin accumulation in yeast and contributing to heme imbalance in human cancers.
This study employs developmental multi-omics to elucidate how provenance-specific regulatory networks and metabolic trajectories coordinate to establish the geo-authenticity and medicinal quality of *Dendrobium officinale*, offering a framework for its evaluation and utilization.
This paper describes *Spermacoce venkatesalui*, a new critically endangered endemic species from the Vellimalai sacred grove in Tamil Nadu, India, distinguishing it from the allied *S. hispida* through detailed morphological analysis and providing a comprehensive taxonomic account.
This study demonstrates that long-term exercise training in Asian competitive athletes is associated with a healthier gut microbiome characterized by higher diversity, beneficial taxonomic enrichment, and enhanced metabolic functions, which can be accurately distinguished from sedentary individuals using machine learning models to identify potential biomarkers for exercise adaptation.
This study presents a rigorously validated catalog of taxonomically restricted and de novo genes in the *Anopheles gambiae* species complex by overcoming assembly artifacts and homology-detection failures through a cross-species core-family framework, revealing that these lineage-specific innovations are transcribed, constrained, and exhibit a structural disorder gradient consistent with de novo gene birth models.
Single-cell analysis reveals that while both YbeX and YbeY are involved in ribosome biogenesis, YbeX deletion under magnesium limitation causes heterogeneous accumulation of 17S pre-rRNA across individual cells leading to a lag phase, whereas YbeY deletion results in more uniform pre-rRNA accumulation during exponential growth, indicating distinct mechanisms of action for these proteins.