4194 papers
This study demonstrates that testosterone supplementation alone is sufficient to drive in vitro spermatogenesis up to the elongated spermatid stage in Leydig cell-deficient mouse testes, provided that the hormone is administered at an optimal concentration of 0.01 µM to ensure efficient progression.
Using a Cre-dependent viral strategy to express A53T-α-synuclein in specific catecholaminergic populations, this study demonstrates that while the same pathogenic trigger induces neurodegeneration in both the substantia nigra and locus coeruleus, the resulting clinical trajectories diverge significantly, with nigral pathology causing severe motor impairment and locus coeruleus pathology leading to milder anxiety-like behaviors, thereby revealing that synucleinopathy vulnerability and dysfunction are determined by cell-type and circuit context.
This study demonstrates that stress enhances vigilance not by globally amplifying neural activity, but by selectively reorganizing a specific claustral subpopulation to remap spatial and social vigilance ensembles with enhanced representational strength.
This study demonstrates that *Akkermansia muciniphila* supplementation alleviates circadian rhythm disruption-induced intestinal barrier injury by activating the KEAP1–NRF2 antioxidant pathway, thereby restoring gut barrier integrity and mitigating oxidative stress.
This study presents the 3.9 Å cryo-EM structure of the African swine fever virus Early Transcription Factor (AETF), revealing its unique domain composition and ubiquitin-mediated regulation, and identifies it as a prototypical ancestral transcription initiation complex for Nucleocytoplasmic Large DNA Viruses.
This study characterizes an extensively drug-resistant *Klebsiella pneumoniae* clinical isolate (KP234) co-harboring *bla*<sub>NDM-5</sub> and *bla*<sub>KPC-2</sub> genes, revealing that the *bla*<sub>NDM-5</sub>-carrying plasmid is a novel hybrid structure formed by the integration and rearrangement of genetic fragments, which poses a significant threat to the efficacy of ceftazidime-avibactam treatment.
This study utilizes high-density SNP data and machine learning to characterize the population structure and identify selection signatures for milk production and adaptation in genetically admixed Sub-Saharan African cattle, providing critical insights for their conservation and sustainable genetic improvement.
This ERP study demonstrates that negative evidence enhances the strength of general inductive arguments by revealing distinct neural mechanisms, including conflict detection and property inference, that operate differently from positive evidence during semantic categorization and reasoning.
This study demonstrates that chronic dietary exposure to microcystin-LR induces coordinated oxidative stress, physiological distress, and organ-specific immune modulation in crucian carp, leading to growth impairment, hepatocellular damage, and hematological dysfunction.
This study presents a 2.77 Å cryo-EM structure of the full-length APOBEC3B complex with EBV BORF2, revealing how the virus neutralizes this cancer-associated mutator through the formation of an elongated hetero-octamer driven by coordinated dual-domain engagement that occludes the catalytic site and stabilizes higher-order BORF2 assemblies.