4194 papers
Despite lacking canonical gravitropism genes, the reduced aquatic angiosperm *Wolffia australiana* exhibits robust, coordinated transcriptional responses to varying gravity levels—particularly involving circadian clock genes—along with distinct morphological and growth adaptations that hold significant promise for space agriculture.
This study establishes a novel multisystem pipeline utilizing complementary non-mammalian and mammalian models to characterize conserved mitochondrial complex I disease phenotypes and identify lutein and vitamin B12 as effective suppressors that rescue these defects through neurometabolic rewiring.
This study employs comparative genomics to characterize three distinct Bangladeshi rhizobia strains (R. bangladeshense BLR175, R. binae BLR195, and R. lentis BLR27), revealing significant genomic divergence and unique, complementary functional traits related to metal homeostasis, phosphate utilization, and stress mitigation that position them as promising candidate bioinoculants.
This study found that while the TRPM6 rs2274924 polymorphism and promoter methylation levels are not associated with idiopathic pulmonary arterial hypertension (IPAH), the rs3750425 CT heterozygous genotype may contribute to IPAH susceptibility, potentially through magnesium-related mechanisms.
This systematic review evaluates 50 studies published between 2010 and 2026 to demonstrate how *Caenorhabditis elegans* models, established via transgenic or toxin-induced methods, serve as powerful preclinical tools for elucidating Parkinson's disease mechanisms and accelerating drug discovery through the targeting of alpha-synuclein aggregation, oxidative stress, and metabolic signaling.
This study demonstrates that while neutrophil molecular profiles globally diverge across COVID-19 and ARDS severity cohorts, the specific geometric relationships between mild and severe states are context-dependent and not transportable, thereby refuting the existence of an invariant one-dimensional severity geometry and highlighting the limitations of cross-sectional abundance data in identifying biological mechanisms or clinical utility.
This study demonstrates that mesenchymal stem cell-derived exosomes and peptides extracted from MO placenta effectively mitigate oxidative stress in adult dermal fibroblasts and significantly enhance angiogenesis in human umbilical vein endothelial cells, highlighting their potential as cell-free regenerative therapies.
This study demonstrates that TGF-β-polarized macrophages, unlike IL-4-polarized macrophages, induce fibrotic responses in human lung fibroblasts by secreting high-molecular-weight factors that activate the TGF-β signaling pathway.
This study demonstrates that the actin-severing protein Wdr1 is essential for primary cilia assembly by promoting Cofilin-mediated actin filament severing and dynamic cytoskeletal remodeling, which facilitates centrosome migration to the apical membrane.
This study reports the development and characterization of two DNA aptamers (Apt 311 and Apt 312) that allosterically inhibit bacterial translation initiation by binding to the essential factor IF2, thereby impeding initiator tRNA accommodation and subunit joining without affecting initial tRNA binding.