🧬 Category

q-bio

4194 papers

🧬 biology

From ceilings to corrected estimates: capture–recapture on reference networks rescales, but rarely reorders, gene regulatory network benchmarks

This study demonstrates that while reference database incompleteness severely limits the absolute accuracy of gene regulatory network benchmarks, applying capture–recapture-based corrections reveals that the relative ranking of inference methods remains robust and largely unchanged despite significant uncertainty in the estimated size of the true interactome.

Liu Chen2026-08-11
🧬 biology

Machine-Learning Modeling of DARWIN Handwriting Features for Alzheimer’s Disease Classification: A Secondary Analysis

This secondary analysis of the DARWIN dataset demonstrates that a machine-learning model using a reduced subset of 10 handwriting tasks achieves classification accuracy for Alzheimer's disease comparable to the full 25-task set, suggesting that shorter, memory-focused assessments could effectively streamline screening without sacrificing performance.

Sanjay Singhvi, Riddhi Singhvi2026-08-11
🧬 biology

Transcriptomic Signatures of Transition from Late Pregnancy to Postpartum

This study utilized RNA sequencing of peripheral blood from 112 healthy women to identify 293 differentially expressed genes that characterize the systemic transcriptomic shift from late pregnancy to the postpartum period, revealing a transition from innate, granulocyte-driven immunity and erythropoiesis toward adaptive, antibody-mediated defense and altered metabolic pathways.

Eugenio Del Prete, Mirac Nur Musaoğlu, Ettore Aiello, Christina Zjukovskaja, Svenja Mager, Veerle Bergink, Fatih Özel, A (…)2026-08-11
🧬 biology

GAPDH nuclear signaling regulates neutrophil migration and inflammatory skin responses

This study identifies a conserved, non-canonical signaling pathway where nuclear GAPDH in neutrophils promotes chronic skin inflammation by enhancing *il4* transcription via H3K27 acetylation, suggesting that inhibiting this nuclear translocation could serve as a therapeutic strategy for inflammatory skin diseases like psoriasis.

Victoriano Mulero, Joaquin Canton-Sandoval, Francisco Martinez-Morcillo, Natalia Perez-Escudero, Isabel Cabas, Beatriz B (…)2026-08-11
🧬 biology

Quantitative Insights into Common and Organ-Specific Aging Gaps via Integrated Multi-Omics Analysis

This study leverages UK Biobank multi-omics data to define and validate distinct common and organ-specific biological age gaps, revealing their unique molecular signatures and enhancing disease prediction through integrated risk scores, with all findings made accessible via the HONOR database.

Sijia Wang, He Huang, Yi Li, Qinglin Song, Liyun Yuan, Yuqi Yang, Renliang Sun, Yue Hu, Chenyihang Xiong, Ting Ni, Yun L (…)2026-08-11
🧬 biology

A Noncanonical Reducing-Domain Architecture Defines a New Class of Modular Polyketide Synthases

This study utilizes cryo-electron microscopy to reveal a novel, noncanonical crossed architecture for the colibactin biosynthetic enzyme ClbB, defining a new class of modular polyketide synthases with unique domain-embedding features that are broadly distributed across bacterial phyla and offer new principles for synthetic biology.

Jin Young Kang, Jinwoo Kim, Byeongsub Lee, Jongseok Park, Hyeongwoo Kim, Minjae Kim, Gyu Sung Lee, Chung Sub Kim, Hyun U (…)2026-08-11