4194 papers
This study utilizes an agent-based model to demonstrate that the risk and trajectory of a potential HPAI H5N1 outbreak in Australia are heavily dependent on the incursion region, highlighting substantial threats to both poultry and wildlife populations to inform targeted national preparedness and One Health strategies.
This study reveals that a specialized subpopulation of melanocytes within congenital nevi autonomously synthesizes and secretes type I, III, and VI collagens along with matrix metalloproteinases, demonstrating that these cells actively construct their dense collagen microenvironment rather than merely residing within it.
This study demonstrates that andrographolide sulfonate alleviates LPS-induced cytokine storm by restoring immune restraint and blocking pyroptosis through IFIT2-mediated suppression of the TLR4/Caspase-1/GSDMD signaling pathway, utilizing a novel spatial pharmaco-proteomics framework to elucidate its tissue distribution and molecular mechanisms.
This study demonstrates that the color of a non-caloric mouth rinse alters sweetness perception, modulates prefrontal cortical activity in trained cyclists, and paradoxically enhances cycling performance when the color is incongruent with sweetness expectations.
Chronic exposure to the environmentally relevant concentration of 1 µg/L atrazine induces redox imbalance, high mortality, developmental malformations, and neuromuscular impairment in zebrafish by increasing reactive oxygen species while depleting antioxidant defenses and inhibiting acetylcholinesterase activity.
This study demonstrates that fucoxanthin induces apoptosis in acute lymphoblastic leukemia Nalm6 cells by triggering endoplasmic reticulum stress via the GRP78-PERK-CHOP signaling axis, which subsequently causes mitochondrial damage and cell cycle arrest, with enhanced efficacy observed when combined with dexamethasone.
This study demonstrates that both high-quality enriched housing and androgen-related physical traits independently enhance male mice's motivation to produce courtship songs, with enriched housing specifically reducing singing latencies and increasing responsiveness to female cues even when controlling for physical traits.
This study reveals that insects have evolved convergent "front-end" desaturase activity within the SCD-like FAD-B subfamily to biosynthesize essential eicosanoid precursors, thereby filling a critical gap in understanding insect lipid metabolism despite the absence of canonical desaturases.
This study evaluated the relationship between SOX10-positive cancer stem cells and cancer-associated fibroblasts in oropharyngeal squamous cell carcinoma, finding that while SOX10 expression predicts shorter relapse time, it does not correlate with CAF levels or specific microRNA expression.
This study utilizes integrated multi-omics analysis of fecal samples to reveal that infantile cholestatic hepatopathy is characterized by specific gut microbiota dysbiosis and metabolic disturbances, identifying nine key metabolites linked to three bacterial genera (*Veillonella*, *Actinomyces*, and *Bifidobacterium*) as potential mechanistic drivers and therapeutic targets.