🧬 Category

q-bio

4194 papers

🧬 biology

Integrated transcriptomic, machine-learning and structural analyses prioritize NR3C1 for experimental follow-up in colorectal cancer

This study integrates transcriptomic, machine learning, and structural analyses to identify and prioritize the glucocorticoid receptor NR3C1 as the most stable and promising candidate for experimental follow-up in resveratrol-mediated colorectal cancer research, while explicitly noting that these findings are hypothesis-generating rather than proof of direct binding.

Zekai Lin^, Yu Ning^, Qi Wu^, Zhongwei Zhou^, Bo Ning^, Xueliang Yang^2026-08-10
🧬 biology

A Multi-omics Analysis of Lung Tissue to Determine an Appropriate Sensitization Concentration in an Ovalbumin-Induced Allergic Rhinitis Mouse Model

This study utilized a multi-omics approach combined with histological and behavioral assessments to demonstrate that a high-concentration ovalbumin sensitization protocol is the most appropriate method for establishing a robust and pathophysiologically accurate allergic rhinitis mouse model, as evidenced by significant IgE elevation, inflammatory infiltration, and activation of the interleukin-17 signaling pathway.

Yihang Zhao, Hong Pan, Zhen Liu, Yandan Wang, Lei Li2026-08-10
🧬 biology

Effects of Different Host Plants on the Age-Stage, Two-Sex Life Table of Bradysia odoriphaga (Diptera: Sciaridae)

This study utilizes age-stage, two-sex life table parameters to demonstrate how seven host plants differentially influence the development, survival, and reproduction of the chive maggot *Bradysia odoriphaga* in cold Heilongjiang, identifying specific hosts that either promote or suppress population growth to inform ecological pest management and crop rotation strategies.

Huan Meng, Yuanlong Chen, Zhenhua Xu, Jiayi Cao, Siwei Pu, Tianqi Luo, Xinrui Wang, Jingqiang Cao, Peng Ma, Fengshan Yan (…)2026-08-10
🧬 biology

From divergence to contact: demographic history and genomic context shape introgression across independent damselfly hybrid zones

By analyzing three independent hybrid zones between *Ischnura elegans* and *Ischnura graellsii*, this study demonstrates that while demographic history drives geographic heterogeneity in introgression patterns, chromosome architecture consistently constrains gene flow, particularly on the X chromosome.

Rosa Sánchez Guillén, Miguel Stand-Pérez, Luís Rodrigo Arce-Valdés, Jesús Ordaz-Morales, Janne Swaegers, Jesús Ramsés Ch (…)2026-08-10
🧬 biology

Wild Birds as Trypanosoma cruzi reservoirs in Pampa biome, Rio Grande do Sul-Brazil: occurrence and molecular detection

This study challenges the traditional view of avian resistance by demonstrating, through molecular detection in 38.7% of sampled wild birds in Brazil's Pampa biome, that diverse bird species harbor *Trypanosoma cruzi* in multiple organs and may serve as significant reservoirs in Chagas disease transmission cycles.

Gustavo Cardoso Ferreira Klann, William Cardoso Ferreira Zorrer, Bibiana Domingues Freitas, Estefani Rinaldi, Nilseia Fe (…)2026-08-10
🧬 biology

Elucidation of Genome Wide Selection Signatures for Milk Production and Adaptive Traits in N’dama African Cattle

This study utilizes genome-wide selection signatures (ROH, iHS, and Tajima's D) to identify candidate genes in N'Dama cattle that underlie both milk production and adaptive traits, such as trypanotolerance and thermal adaptation, providing a genetic foundation for future breeding programs.

Kazeem Ajasa, Gargi Ramola, Uddhav Paneru, Moshood Abiola Popoola, Anupama Mukherjee, Sabyasachi Mukherjee2026-08-10
🧬 biology

Circulating CD4+ T-Cell Differentiation Subsets Are Redistributed in HTLV-1–Associated Adult T-Cell Leukemia/Lymphoma

This study demonstrates that Adult T-cell Leukemia/Lymphoma (ATLL) is characterized by a significant redistribution of circulating CD4+ T-cell subsets, specifically a contraction of naïve and central memory cells alongside an expansion of effector memory cells, independent of age, sex, or the presumed HTLV-1 transmission route.

Jéssica Bilar Cavalcanti¹, Priscila Lima Barros¹, Davi Ferreira Jofre¹, Giulia Sales Guimarães¹, Karine Sobral Marques¹ (…)2026-08-10
🧬 biology

Choosing among Competing Pockets in Oligomeric Proteins: An OIPS-Assisted, Traceable Multi-Evidence Analysis

The paper introduces OIPS, a traceable, multi-evidence framework that successfully prioritizes competing binding pockets in oligomeric proteins by integrating geometric, ligandability, and assembly-specific data, achieving high accuracy in identifying reference sites while balancing retrospective recovery with the preservation of assembly-supported alternatives.

晓 陈, Yifan Zhu, Shilei Zhao, Xin Zhang, Haopeng Sun, Yao Chen, Xin Xue2026-08-10