🧬 Category

q-bio

4194 papers

🧬 biology

A leakage-aware benchmark for evaluating chemical and cellular generalization in single-cell perturbation-response prediction

This paper introduces a leakage-aware benchmark framework that explicitly defines train-test neighborhoods to rigorously evaluate single-cell perturbation models' generalization capabilities across chemical and cellular contexts, revealing that standard random splits often overestimate performance by retaining structural and mechanistic overlaps that joint held-out validation successfully eliminates.

Da Lin¹, Ying Chen², Yue Liu², Yu Zhang¹2026-08-10
🧬 biology

Mirror Symmetry Drug Design (MSDD): A Parity-Inversion Framework for Generative De Novo Design of Proteolytically Stable Dual-Targeting D-Peptides against Bcl-2 and Mcl-1

The paper introduces Mirror Symmetry Drug Design (MSDD), a novel computational framework that circumvents the chiral limitations of current generative AI by inverting target protein pockets to enable the de novo design of proteolytically stable, high-affinity D-peptide dual inhibitors for Bcl-2 and Mcl-1 without requiring model retraining.

Sharon Melhi2026-08-10
🧬 biology

Occupancy-Driven Attenuation in Radiation-Sensitive Chromatin Domains: A Statistical-Mechanical Model of the Overkill Effect and RBE Maximum

This paper proposes a statistical-mechanical model demonstrating that the "overkill effect" and the resulting maximum in relative biological effectiveness (RBE) arise from the progressive occupancy of finite radiation-sensitive chromatin domains, which limits the formation of additional lethal events at high linear energy transfer (LET).

Ladan Rezaee2026-08-10
🧬 biology

Heterozygous HMGB1 variants and neurodevelopmental disorder: phenotypic and allelic spectrum

This international study characterizes the phenotypic and allelic spectrum of a neurodevelopmental disorder caused by heterozygous *HMGB1* variants, distinguishing it from BPTAS by confirming that while microcephaly is common, the disorder encompasses diverse coding and noncoding mutations that do not generate the arginine-rich C-terminal tail associated with the latter syndrome.

Himanshu Goel, Kayla Treat, Theodore Wilson, Angela Peron, Manuela Morleo, Vincenzo Nigro, Konrad Platzer, Rosanna Krako (…)2026-08-10
🧬 biology

Transcriptomic and Metabolic Basis of Volatile Compound Dynamics in Apricot Fermentation

This study elucidates the temporal dynamics of aroma biosynthesis in *Wickerhamomyces anomalus* LY13 during apricot residue fermentation, revealing that key volatile compounds peak at 48 hours driven by early gene induction and identifying a specific short-chain alcohol dehydrogenase (WICANDRAFT_98376) responsible for converting phenylacetaldehyde to 2-phenylethanol.

Lei Li, Yunfei Chen, Zhifei Chen, Jiaming Zhao, Xueying Cao, Haoyang Chen, Gaolei Xi, Li Han, Xingwang Song2026-08-10
🧬 biology

Invasion status and mycorrhizal responsiveness jointly shape context-dependent plant-soil feedbacks in Northern Great Plains grasslands

This study demonstrates that in Northern Great Plains grasslands, mycorrhizal responsiveness alone does not determine positive plant-soil feedbacks; rather, a positive feedback legacy is uniquely generated by the invasive leafy spurge through a combination of enemy release and mutualist accumulation, whereas native mycorrhizal-responsive species accumulate negative feedbacks driven by soil pathogens.

Rebeca Crespo-Teixeira, Hanh N. H. Pham, Jonathan A. Bennett2026-08-10
🧬 biology

Scalable regional genomic surveillance reveals previously unrecognized SARS-CoV-2 recombinant diversity and limited onward transmission

By analyzing 3,360 SARS-CoV-2 genomes from northeastern Germany with a novel two-stage detection framework, this study reveals significant unrecognized recombinant diversity and demonstrates that while co-infections are frequent, successful onward transmission of recombinants remains a major evolutionary constraint.

Christian Kohler, Ana Tzvetkova, Anne Pohlmann, Kathrin Lehmann, Tilo Sasse, Veronika Balau, Martin Beer, Lars Kaderali (…)2026-08-10
🧬 biology

Segmentation and profile-based classification of movement strategies from animal tracking data

This paper introduces a profile-based classification framework that segments animal GPS trajectories and classifies movement strategies using empirical behavioral profiles and bootstrapping to provide probabilistic assignments with uncertainty estimates, requiring only modest training data and demonstrating high accuracy across simulations and two ecologically distinct species.

Ivo Kadlec, Johannes Signer, Martin Sládeček, Miroslav Kutal, Martin Duľa, Aldin Selimović, Vendula Meissner-Hylanova, N (…)2026-08-10
🧬 biology

Cognitive, Behavioral, and Sleep Characterization of Sex Differences in the Ts65Dn Mouse Model of Down syndrome

This study reveals significant sex differences in the Ts65Dn mouse model of Down syndrome, where females exhibit superior recognition memory, reduced depression-like behavior, and more stable sleep compared to males, highlighting the critical need to account for sex-specific variations in future research and therapeutic strategies.

Tula Lawsin Kurashige, Stella Tapia Lopez, Sadie Peroulas, Lauren Chan, H. Craig Heller, Elsa Pittaras2026-08-10