4194 papers
This study successfully established a CHO-based expression and purification system for recombinant porcine interleukin-6, confirming its high purity and demonstrating its biological activity through the upregulation of specific genes in porcine macrophages and the promotion of cell migration in B16F10 cells.
This study elucidates the genetic architecture of complex coat color variation in Lufeng cattle by integrating population genomics and epigenomics to reveal that background pigmentation and white-pattern distribution are driven by partially independent mechanisms involving wild bovine introgression, regulatory variation, and specific candidate genes.
This study demonstrates that tangeretin protects TM3 Leydig cells from polystyrene nanoplastic-induced oxidative stress and steroidogenic dysfunction by modulating the NOX4/Nrf2 signaling axis and preserving testosterone production, as validated through combined in vitro experiments and molecular docking simulations.
This paper establishes a variance-component criterion to determine when internal-control normalization improves molecular quantification on the Ct scale, demonstrating that estimating an optimal control coefficient is generally more robust than assuming a unit coefficient, particularly when the shared processing variance exceeds the sum of control-specific and measurement variances.
This study demonstrates that the BR-ArboTrap, a passive surveillance device using honey-baited FTA cards, effectively captures diverse vertebrate-associated and zoonotic viral signals from mosquito salivary deposits in northeastern Brazil, offering a scalable, cold-chain-independent strategy for early detection of emerging pathogens.
The paper introduces LLM-H2G, a biomedical semantic-enhanced hypergraph contrastive learning framework that integrates large language model-derived text embeddings with heterogeneous hypergraph structures to significantly improve the prediction and interpretability of herb–disease associations, particularly in sparse networks.
This study demonstrates that Mycobacterium tuberculosis infection triggers phosphorylation of dynamin-related protein 1 at Ser616 in macrophages, which drives ROS-mediated HIF-1α stabilization to promote xenophagic clearance of the bacteria, thereby identifying Drp1 S616 phosphorylation as a critical host-directed therapeutic target for tuberculosis.
This paper proposes a 3D reaction-diffusion-chemotaxis model demonstrating that the mycorrhizal "Wood Wide Web" functions as a distributed PID controller in a closed ecological reactor, providing parametric resilience that maintains stable CO₂ levels despite significant fluctuations in cooperation coefficients and signal speeds.
This study demonstrates that SNARE-derived coiled-coil domains from *Saccharomyces cerevisiae* serve as a programmable, orthogonal toolkit for spatially organizing metabolic enzymes in *E. coli*, successfully doubling astaxanthin production without compromising host growth.
This study demonstrates that 3D HepaRG liver spheroids, particularly in coculture with hepatic stellate cells, serve as a reproducible, cost-effective, and physiologically relevant in vitro platform for predicting drug-induced liver injury by integrating multiple functional endpoints to achieve high classification accuracy.