4194 papers
This study demonstrates that knocking down the mechanosensitive ion channel Piezo1 sensitizes glioblastoma cells to focused ultrasound-induced apoptosis by preventing physical detachment and inhibiting long-term proliferation, thereby suggesting Piezo1 inhibition as a strategy to enhance the cytotoxic efficacy of FUS therapy.
This study utilized genome-wide SNP markers to characterize a vegetable soybean core collection and Sub-Saharan African elite grain soybeans, revealing three distinct genetic groups with high diversity in vegetable accessions that offer a valuable foundation for breeding improved cultivars in Sub-Saharan Africa.
This study demonstrates that hypertension-mediated cardiac fibrosis is a mechanical process initiated by smooth muscle cells through Lysyl oxidase-dependent extracellular matrix modification, rather than by fibroblasts, revealing a distinct therapeutic target to uncouple fibrosis from other hypertensive cardiac remodeling.
This study demonstrates that 60 days of simulated microgravity induces phase-dependent alterations in working memory performance and intrinsic neural timescales across delta and theta bands, which are linked to adaptive reorganizations of cortical excitatory-inhibitory balance and recover upon return to baseline conditions.
A study of 1,000 heterosexual women reveals that while high-cost altruism is preferred for short-term mating, moderately costly altruism is rated as more attractive for long-term relationships, suggesting that the optimal signaling of male mate value depends on both the cost of the altruistic act and the mating context.
This study presents the first comprehensive viral metagenomic analysis of the Shroud of Turin, revealing distinct spatial patterns of human and environmental viruses, discovering novel viral genomes including a new species named *Sindonivirus turinense*, and identifying molecular evidence linking the artifact's history to the 1532 Chambery fire and its saline preservation conditions.
This study demonstrates that a green ultrasound-assisted synthesis of a Halloysite-Silver nanocomposite using *Acalypha australis* extract effectively inhibits *E. coli* biofilm formation by significantly downregulating the expression of the *fimH* and *mrkD* genes.
This paper demonstrates that coupling evidence-dependent bistability to a dependency structure creates a recovery geometry where the interplay between gating mechanisms and coupling strength determines whether an adaptive system converges to full recovery, total collapse, or a stable partial state.
This laboratory-based study demonstrates that exposing human whole blood to clinical bacterial isolates generally elicits dose-dependent increases in Interleukin-6 production, although the magnitude of this inflammatory response varies significantly across different bacterial species.
This study demonstrates that increasing vegetation cover in high-alpine permafrost soils reshapes microbial community structure and metabolic potential by altering key soil properties like pH and C:N ratio, thereby driving a shift toward specialist taxa with enhanced carbon cycling capabilities and influencing greenhouse gas emissions under climate warming.