🧬 Category

q-bio

4194 papers

🧬 biology

Integration of single-cell sequencing and experimental validation identified P2RY13/NF-κB as an immunological factor of patients with colorectal cancer

This study integrates single-cell and spatial transcriptomics with experimental validation to identify P2RY13 as a novel prognostic marker that suppresses colorectal cancer progression and M2 macrophage polarization by inhibiting the NF-κB pathway, while also characterizing distinct pro-inflammatory and pro-tumor macrophage subpopulations to inform precision immunotherapy strategies.

Xueping Xiang, Xi Xu, Tingting Cui, Kexin Wang, Zejun Fang2026-08-10
🧬 biology

Identification of Novel Candidate Inhibitors Targeting hBCATm for Acute Liver Failure by In Silico Methods

This study utilized a sequential in silico workflow, including molecular docking, derivatization, molecular dynamics simulations, and MMGBSA calculations, to identify two novel candidate molecules (L-78 and L-87) that exhibit superior binding affinity and stability to human mitochondrial branched-chain aminotransferase (hBCATm) compared to the reference drug Azathioprine, suggesting their potential as therapeutic leads for acute liver failure.

Remziye Azra Kartop, Serra Özışık, Vildan Enisoğlu Atalay2026-08-10
🧬 biology

Implications of Land–Use and Land-Cover Change on Distribution of Large Mammals Following the Gazettement of Ugalla River National Park, Western Tanzania

This study demonstrates that elevating Ugalla River's status to a strictly protected National Park in 2019 triggered significant habitat restoration and a 78% reduction in cropland, leading to distinct spatial distributions of large mammals that favor grasslands over woodlands and validating strict protection as a high-impact strategy for achieving global biodiversity targets.

Ismail. O. Ismail, Chacha Werema, Steven E. Temu2026-08-08
🧬 biology

Spatio-Temporal Expression of the Somatotropic Axis Genes Across Ontogenetic Stages in Rainbow Trout (Oncorhynchus mykiss)

This study characterizes the spatio-temporal expression patterns of five somatotropic axis genes across six developmental stages in rainbow trout, revealing distinct tissue-specific peaks and regulatory dynamics that define key windows for somatic growth and reproductive transition, thereby establishing a transcriptional baseline to optimize aquaculture breeding and feeding strategies.

Ja’afar Yusuf, Irfan Ahmad Bhat, Irfan Ahmad Khan, Mir Ishfaq Nazir, Shabir A. Dar, M. M. Kirmani, Mohd Ashraf Rather2026-08-08
🧬 biology

Large mammal population density responses to park gazettement: Evidence from Ugalla River National Park, Tanzania

This study demonstrates that the 2019 gazettement of Ugalla River National Park in Tanzania catalyzed early, species-specific population recoveries for several large mammals, indicating that enhanced protection can initiate ecological restoration in historically degraded ecosystems despite constraints from past disturbances and life-history traits.

Ismail .O. Ismail, Chacha Werema, Steven. E. Temu2026-08-08
🧬 biology

The spectrum of PAH variants and genotype-phenotype correlation in patients with phenylalanine hydroxylase deficiency in Inner Mongolia, China

This study characterizes the unique spectrum of PAH variants and genotype-phenotype correlations in Inner Mongolian patients with phenylketonuria, identifying three novel mutations and demonstrating that the APV/GPV model achieves an 83.53% concordance rate for predicting clinical outcomes.

Lichun Zhang, Lirong Zhao, Bo Zhu, Wenguang Kang, Gang Wang, Wenli Wang, Xinyan Li, Yunjian Song, Xiaohua Wang, Jie Wang2026-08-07
🧬 biology

The polygenic risk score and inter-familial heterogeneity in multigenerational families affected by schizophrenia and bipolar disorder

This study of multigenerational families with schizophrenia and bipolar disorder reveals that while polygenic risk scores are generally elevated in affected individuals and their relatives, significant inter-familial heterogeneity and low-risk transmission profiles indicate that polygenic inheritance alone cannot fully explain disease transmission, suggesting the involvement of other genetic or environmental factors.

Simon L. Girard, Jasmin Ricard, Alix Dubeau, Claudia Moreau, Marie-Claude Boisvert, Michel Maziade, Alexandre Bureau2026-08-07
🧬 biology

Doxorubicin Drives Chemoresistance in Osteosarcoma by Inducing Adaptive Plasticity and IL-1β/COX-2-mediated Inflammation

This study reveals that doxorubicin treatment inadvertently drives chemoresistance in osteosarcoma by inducing cancer stem cell-like plasticity and epithelial-mesenchymal transition through a self-amplifying IL-1β/COX-2 inflammatory axis that can be disrupted to restore drug sensitivity.

Purin Somnuake, Su Yati, Aitthiphon Chongchai, Sureerut Porntadavity, Theerawut Chanmee2026-08-07
🧬 biology

Effects of an intensive firefighter training program on a simulated fire-escape staircase climb

A four-week intensive training program significantly improved firefighters' weighted stair-climb performance primarily through neuromuscular and anaerobic adaptations rather than changes in aerobic capacity or body mass, with post-training performance strongly predicted by strength and anaerobic power metrics.

Carlos Sanchis, José Martí-Martí, Juan Bautista Miñana, Didac Navarro-Martínez, Javier Zahonero, Cristina Monleón2026-08-07