4194 papers
This case-control study demonstrates that the miR-126 rs4636297 and miR-143 rs4705342 polymorphisms individually and synergistically influence atherosclerosis risk in an Iranian population, with functional in silico analysis confirming their regulatory roles in gene expression and splicing.
By analyzing the microanatomy of osteoderms in Australian Egernia-group lizards using high-resolution µCT, this study demonstrates that specific structural adaptations in these skin bones serve functional roles beyond armor, such as water retention in dry habitats and mechanical reinforcement for burrowing, thereby providing new tools for reconstructing the lifestyles of extinct vertebrates.
UNIPRO is a unified graph-based framework that leverages existing CITE-seq resources to jointly model transcriptomic similarity and spatial context, enabling accurate protein inference, spatial reconstruction, and panel expansion across diverse single-cell and spatial transcriptomics datasets.
This study reveals that breeding emperor penguins from Snow Hill Island in the northwestern Weddell Sea exhibit strong fidelity to specific shelf/slope-associated foraging areas across contrasting sea-ice seasons, with their habitat use influenced by sea-ice concentration and distance from the colony, thereby validating the relevance of the proposed Weddell Sea Marine Protected Area for their conservation.
In male lung adenocarcinoma, a genomically validated loss of chromosome Y (LOY) transcriptional program serves as a modest, statistically significant prognostic signal that is only marginally independent of tumor stage and is largely confounded by generic proliferation, limiting its immediate utility as a standalone clinical biomarker.
The paper introduces CHAP-GWAS, a novel, phenotype-driven algorithm that leverages chromosome-scale haplotypes to dynamically define trait-associated blocks, thereby significantly improving statistical power and identifying genetic loci missed by conventional single-SNP and static haplotype-based GWAS methods.
This study demonstrates that 3D-printed coral-inspired shelters with enlarged geometries significantly increase reef fish abundance and interaction frequency, highlighting the potential of manipulating specific architectural features to optimize artificial reef designs.
This study identifies and functionally characterizes CcTPR4 as a negative regulator of jute fiber yield that suppresses cellulose biosynthesis and modulates gibberellin homeostasis, establishing it as a key target for molecular breeding.
By integrating a large-scale major depressive disorder GWAS with a comprehensive human brain splicing-QTL resource, this study identifies 56 high-confidence candidate effector genes whose disease associations are more clearly resolved through alternative splicing than through gene expression alone, offering a complementary regulatory layer for functional and translational prioritization.
This study provides the first evidence of a substantial shared genetic architecture between premenstrual disorder and postpartum depression through registry-based and genomic analyses, identifying novel risk loci in *PCDH9* and *KCTD16* that implicate GABA-mediated inhibitory signaling and hippocampal regulation in the abnormal brain response to hormonal fluctuations.