4194 papers
This study identifies EphB4⁺ veins within decidual septa as a critical maternal exit pathway that accelerates oxygen-transfer kinetics in the human placenta, demonstrating that their absence in high-risk pregnancies significantly delays oxygen renewal and increases susceptibility to stillbirth.
This study demonstrates that DNA phosphorothioation enhances *Bacillus subtilis* stress tolerance and probiotic efficacy against alcohol-induced gut-liver injury by neutralizing reactive oxygen species and converting taurochenodeoxycholic acid into tauroursodeoxycholic acid to activate host TGR5 signaling, thereby preserving intestinal barrier integrity and suppressing hepatic inflammation.
This study employs an integrative taxonomic approach combining COI DNA barcoding and morphological analysis of genitalia to delimit Empoascini species in Argentine agroecosystems, resulting in the description of a new *Hebata* species, the first description of the female *Matsumurasca aculeata*, and the redescription of the female *M. curveola*.
This study demonstrates that hyaluronic acid-functionalized β-lactoglobulin nanocarriers effectively enhance tumor targeting and pH-responsive doxorubicin delivery via CD44-mediated endocytosis, resulting in superior cytotoxicity and tumor growth inhibition with excellent biocompatibility in both in vitro and in vivo models.
Using data from the German National Cohort, this study demonstrates that smoking is associated with increased microbial diversity and a higher abundance of anaerobic pathobionts in the anterior nares, providing a potential mechanistic explanation for the heightened susceptibility to respiratory infections observed in smokers.
This study characterizes the secondary structural diversity and stability of approximately 150 stress-responsive pre-miRNAs in rice, identifying four distinct structural patterns and significant variations in free energy that may influence their biogenesis and function, thereby providing a foundation for designing miRNA-based strategies to enhance stress tolerance.
This study identifies high CSF1R expression as a prognostic biomarker for poor outcomes in advanced gastric cancer, characterizing this subgroup as having a macrophage-rich tumor microenvironment with enriched inflammatory and T-cell exhaustion pathways.
This genome-wide meta-analysis of 141,505 adults identifies eight genetic loci associated with ADHD symptoms and reveals that inattention and hyperactivity-impulsivity have distinct genetic architectures, with the latter showing stronger links to clinical ADHD diagnoses and educational traits, while the former is more positively associated with educational outcomes.
This study demonstrates that an interpretable machine-learning framework utilizing solely autofluorescence intensity patterns, rather than complex lifetime data or destructive labeling, can reliably distinguish between human pancreatic α- and β-cells based on fine-scale intracellular organization likely reflecting lipofuscin granule distribution.
This study identifies activin A as a microenvironment-derived driver of B-cell acute lymphoblastic leukemia (B-ALL) dissemination and relapse that functions through an ERK1/2–cortactin signaling axis to promote actin polymerization, cell migration, and bone marrow colonization.