4194 papers
This study presents the first comprehensive analysis of MHC class I genes in the Asiatic ibex, revealing high genetic polymorphism maintained by long-term balancing selection and demonstrating that altitudinal gradients modulate the strength of positive selection on specific alleles likely through differential pathogen pressures.
This study confirms the presence of *Angiostrongylus cantonensis* in both synanthropic and wild rodent species in French Guiana, suggesting spillover infections at habitat interfaces and a likely introduction via historical trade routes from the West Indies rather than local Amazonian dispersal.
This study demonstrates that eIF5A is an indispensable protein in eukaryotic cells whose essential function cannot be bypassed by mutations in other pathways, revealing that the paralogous gene *TIF51B* (or *EIF5A2*) serves as a population-level backup system that is normally repressed by Rox1 and Mot3.
This paper presents a unified Safety-by-Design computational framework that integrates virtual patient cohorts, mechanistic immune signatures, synthetic multi-omics, and explainable AI to prioritize RNA-LNP formulations by predicting safety scores and validating biological consistency against independent human single-cell data.
This in vitro study demonstrates that the serotonin modulator and stimulator Brintellix (vortioxetine) exhibits significantly stronger antimicrobial activity against 22 strains of Bifidobacterium compared to the SSRIs Cipralex and Seropram, suggesting that antidepressant class influences their impact on gut microbiota.
The paper introduces ZIP CRISPR, a versatile and cost-effective all-in-one RNP strategy that uses complementary extensions between the gRNA and ssODN template to significantly enhance homology-directed repair efficiency with both Cas9 nuclease and nickase while minimizing genotoxicity.
This study demonstrates that individual variability in attentional capture by distractors embedded in learned spatial-probability histories is positively associated with functional connectivity within the default mode network, suggesting a neural basis for susceptibility to such learned distractors.
This study reveals that prolonged GDF15 exposure impairs bovine granulosa cell proliferation, steroidogenesis, and survival by inducing GFRAL internalization and lysosomal degradation, which suppresses the RET–PI3K/AKT signaling pathway and triggers endoplasmic reticulum stress-associated apoptosis.
This study reveals that Parkinson's disease patients exhibit widespread m6A epitranscriptomic remodeling in peripheral blood mononuclear cells, driven by METTL14 downregulation, which correlates with immune pathway dysregulation and the aberrant stabilization of neurodegeneration-associated transcripts.
This study documents the first quantitative morphometric baseline and reproductive observations for the paper nautilus *Argonauta hians* in Indian waters, confirming its presence off the north-west coast of India through the analysis of seven female specimens and highlighting their negative allometric growth and protracted reproductive cycle.