4194 papers
This study integrates transcriptomics, machine learning, and experimental validation to identify a hub-and-module regulatory system involving ERF, G2-like, bHLH, and MYB-related transcription factors that control gamma-linolenic acid biosynthesis in the moss *Physcomitrium patens*.
This study successfully optimized the production of the haloadapted α-amylase AmyHa from *Haloarcula argentinensis* S3 using response surface methodology to achieve a 1.84-fold yield increase and elucidated its structural and functional adaptations, including a highly acidic surface and a conserved catalytic triad, which enable robust starch hydrolysis under extreme salinity and acidic conditions.
This study reveals that while Protein C maintains involvement in conserved biological pathways across age groups, its specific protein interaction partners and surrounding proteomic networks undergo significant developmental changes, particularly during early life.
This study demonstrates that utilizing a dosage-aware SNP-based genomic relationship matrix to correct pedigrees and refine GWAS models effectively identifies key genetic loci for spittlebug resistance and apomixis in tetraploid *Urochloa* hybrids, thereby accelerating genomic-assisted selection in tropical forage breeding programs.
This study reveals that flotillins facilitate unconventional secretion by establishing contacts between endolysosomes and ER exit sites, thereby promoting the formation of secretory autophagosomes and extracellular vesicles, a mechanism potentially linked to pathological conditions like cancer.
This study demonstrates that in baker's yeast, replicative aging manifests early under harsh environmental conditions, with mitochondrial DNA depletion and SIR2 deletion accelerating stress-induced mortality through mechanisms that partially overlap with those limiting lifespan in optimal conditions.
Despite individual fungal taxa responding to macroclimatic shifts, a study across the range of bur oak reveals that local plant neighborhood composition, rather than climate or soil conditions, is the primary driver structuring soil mycorrhizal fungal communities.
This longitudinal study utilized a hierarchical principal component analysis and K-means clustering to identify three distinct, stable, yet modifiable integrated health-related fitness phenotypes among university students, demonstrating that a 16-week resistance training intervention significantly facilitated upward transitions in fitness profiles for a subset of participants.
This paper introduces a residue-level quantum circuit framework that models protein thermodynamics as heterogeneous ensembles of binary microstates, successfully capturing network-level energetic couplings and ensemble reorganization in miniproteins like Trp-cage and a disulfide-stabilized chimera, thereby advancing quantum protein modeling beyond single-structure optimization.
This study on zoo-housed bonobos found that while nasal temperature decreases did not reliably predict overall affective valence or judgment bias, they were associated with optimistic responses to ambiguous stimuli, suggesting that nasal cooling reflects arousal rather than serving as a direct indicator of positive or negative emotional states.