Integration of single-cell sequencing and experimental validation identified P2RY13/NF-κB as an immunological factor of patients with colorectal cancer
This study integrates single-cell and spatial transcriptomics with experimental validation to identify P2RY13 as a novel prognostic marker that suppresses colorectal cancer progression and M2 macrophage polarization by inhibiting the NF-κB pathway, while also characterizing distinct pro-inflammatory and pro-tumor macrophage subpopulations to inform precision immunotherapy strategies.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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