🧬 Category

q-bio

4198 papers

🧬 biology

Multivariate soil–microbial covariation and constrained recognition of fungal-dominated community-state extremes using Evidence- Constrained Residual Fusion

This study demonstrates that multivariate soil physicochemical conditions covary with a fungal-dominated microbial community state in northern China and evaluates the Evidence-Constrained Residual Fusion (ECRF) method, which achieves high balanced accuracy in identifying community extremes using combined soil and spatial predictors, though its incremental performance over a transparent anchor model is modest and dependent on data partitioning.

Pengyu Zhao, Geng Liu, Yujing Li, Xiaodong Zhao, Donghui Zhang2026-08-06
🧬 biology

EpiNet: A multilayer integrative atlas of the human epigenetic regulatory network reveals principles of complex assembly, domain modularity, and lncRNA scaffolding

This study introduces EpiNet, a multilayer integrative atlas of the human epigenetic regulatory network that reveals the system's hierarchical, modular organization and non-random assembly principles—highlighting WDR5 as a central hub, recurrent Pfam domain signatures, and lncRNA scaffolding—through comprehensive network analysis of curated protein, complex, domain, and lncRNA data.

Amine BOUGARNE2026-08-06
🧬 biology

Aav Capsid Glycoengineering: Effects of Glycan Type, Density and Conjugation Site on Vector Stability, Delivery and Gene Transduction

This study demonstrates that chemically attaching synthetic glycans to specific residues on the AAV9 capsid can modulate vector stability and transduction efficiency, revealing that while high glycan density generally hinders performance, strategic mannosylation—particularly at site M471—significantly enhances gene delivery.

Sergio Milagros, Damian Pérez-Martínez, Samuel Salazar-Díaz, Pablo Ramirez-Ruiz de Erenchun, Marina Nicolao, Beatriz Car (…)2026-08-06
🧬 biology

RFX4 maintains excitatory–inhibitory balance through WNT-dependent cortical patterning: implications for neurodevelopmental disorders

This study demonstrates that the transcription factor RFX4 is essential for maintaining excitatory–inhibitory balance in human cortical organoids by directly regulating WNT signaling, thereby providing a mechanistic link between RFX4 dysfunction and neurodevelopmental disorders.

Min Young Lee, So Jin Kim, Museog Choe, Won Hee Jung, Ye Seong Jeon, Ju Yeon Lee, Sehwan Park, Murim Choi, Hyo Geun Shin (…)2026-08-06
🧬 biology

CCNIF: A Reproducible Causal-Network Framework for Prioritizing and Characterizing Candidate Cancer Driver Genes in Lung Adenocarcinoma

This paper introduces CCNIF, a reproducible computational framework that prioritizes and characterizes candidate cancer driver genes in lung adenocarcinoma by integrating mutation and expression data with multi-domain evidence profiles, successfully validating known drivers like TP53 and EGFR while providing a ranked, confidence-scored panel of candidates for further experimental investigation.

Mohd Sameer, Pankaj Chauhan2026-08-06
🧬 biology

Hepatic injury signals drive proteomic reprogramming of the mesenchymal stem cells secretome to counteract liver damage

This study demonstrates that priming human neonatal mesenchymal stem cells with signals from paracetamol-injured liver cells reprograms their secretome to enhance hepatocyte viability, reduce oxidative stress, and restore metabolic function, thereby supporting the development of targeted secretome-based therapies for acute liver failure.

Ana S. Serras, Sérgio P. Camões, Joana S. Rodrigues, Joel M. Vej-Nielsen, Rui Vitorino, Joana P. Miranda2026-08-06
🧬 biology

Reliance on atmospheric nitrogen increases along a soil salinity gradient and coordinates with ion-regulation and water-use traits in a halophytic desert legume (Halimodendron halodendron)

In the hyper-arid Tarim Basin, the halophytic legume *Halimodendron halodendron* maintains leaf nitrogen levels by increasing its reliance on atmospheric nitrogen fixation as soil salinity rises, but this adaptive strategy cannot prevent growth decline because the physiological costs of ion regulation and water conservation ultimately constrain biomass.

Chang Kun Ma, Qiuping Fu, Quanjiu Wang, Yan Xu, Xiaoxu Jia2026-08-06
🧬 biology

Metagenomic characterization of the gut microbiota of Actinopyga echinites reveals ecological functions and untapped biotechnological potential

This study presents the first metagenomic characterization of the gut microbiota of the vulnerable sea cucumber *Actinopyga echinites* from the Philippines, revealing a stable, diverse microbial community with significant roles in host nutrition and benthic nutrient cycling, as well as untapped potential for biotechnological applications in aquaculture, pharmaceuticals, and environmental bioremediation.

Jomar F. Besoña, Elgen M. Arriesgado, Marjel M. Broce, Fernand F. Fagutao, Marnelle B. Sornito, Erwin Jones A. Tucong, M (…)2026-08-06
🧬 biology

Histone H3S28 Phosphorylation Promotes a Senescence-Associated Survival Program Following PARP Inhibition in Hormone Receptor-Positive Breast Cancer

This study reveals that histone H3S28 phosphorylation, mediated by MSK1/2, acts as a chromatin-based adaptive mechanism that promotes a senescence-associated survival program and contributes to PARP inhibitor resistance in hormone receptor-positive breast cancer.

Anna Tomàs Pujolà, Evangelos Manousakis, Clàudia Martinez Miralles, Houda Baccara, Laia Liñán Franquet, Roberto Ferrari (…)2026-08-06