4205 papers
This study demonstrates that the transcription factor RFX4 is essential for maintaining excitatory–inhibitory balance in human cortical organoids by directly regulating WNT signaling, thereby providing a mechanistic link between RFX4 dysfunction and neurodevelopmental disorders.
This paper introduces CCNIF, a reproducible computational framework that prioritizes and characterizes candidate cancer driver genes in lung adenocarcinoma by integrating mutation and expression data with multi-domain evidence profiles, successfully validating known drivers like TP53 and EGFR while providing a ranked, confidence-scored panel of candidates for further experimental investigation.
This study demonstrates that priming human neonatal mesenchymal stem cells with signals from paracetamol-injured liver cells reprograms their secretome to enhance hepatocyte viability, reduce oxidative stress, and restore metabolic function, thereby supporting the development of targeted secretome-based therapies for acute liver failure.
In the hyper-arid Tarim Basin, the halophytic legume *Halimodendron halodendron* maintains leaf nitrogen levels by increasing its reliance on atmospheric nitrogen fixation as soil salinity rises, but this adaptive strategy cannot prevent growth decline because the physiological costs of ion regulation and water conservation ultimately constrain biomass.
This study presents the first metagenomic characterization of the gut microbiota of the vulnerable sea cucumber *Actinopyga echinites* from the Philippines, revealing a stable, diverse microbial community with significant roles in host nutrition and benthic nutrient cycling, as well as untapped potential for biotechnological applications in aquaculture, pharmaceuticals, and environmental bioremediation.
This study reveals that histone H3S28 phosphorylation, mediated by MSK1/2, acts as a chromatin-based adaptive mechanism that promotes a senescence-associated survival program and contributes to PARP inhibitor resistance in hormone receptor-positive breast cancer.
This study utilizes an integrated computational pipeline to identify Brassicasterol, a sterol-derived metabolite from *Cordyceps militaris*, as a promising novel antimalarial lead with superior binding affinity and stability against *Plasmodium falciparum* targets compared to the reference drug Artemisinin.
This study identifies soil in Tanzania as a significant reservoir of antimicrobial resistance, revealing that Gram-negative bacterial isolates exhibit high resistance to β-lactams and highlighting the need to integrate environmental surveillance into the country's One Health monitoring framework.
This study establishes a novel, stable, and easy-to-operate mouse model of idiopathic pulmonary fibrosis using in situ left-lung bleomycin injection, which demonstrates superior consistency and survival rates compared to traditional intratracheal instillation and effectively validates the antifibrotic efficacy of nintedanib.
This study employs a novel coupled state-space inference (CSSI) framework to computationally demonstrate that the stability of reversed uridine-tetrad RNA G-quadruplex caps is encoded by a cooperative mechanism involving backbone reversal, cap–core stacking, and terminal cation organization, yielding calibrated predictions that support a falsifiable clamp–stack–ion energetic model.