4211 papers
This study reveals that histone H3S28 phosphorylation, mediated by MSK1/2, acts as a chromatin-based adaptive mechanism that promotes a senescence-associated survival program and contributes to PARP inhibitor resistance in hormone receptor-positive breast cancer.
This study utilizes an integrated computational pipeline to identify Brassicasterol, a sterol-derived metabolite from *Cordyceps militaris*, as a promising novel antimalarial lead with superior binding affinity and stability against *Plasmodium falciparum* targets compared to the reference drug Artemisinin.
This study identifies soil in Tanzania as a significant reservoir of antimicrobial resistance, revealing that Gram-negative bacterial isolates exhibit high resistance to β-lactams and highlighting the need to integrate environmental surveillance into the country's One Health monitoring framework.
This study establishes a novel, stable, and easy-to-operate mouse model of idiopathic pulmonary fibrosis using in situ left-lung bleomycin injection, which demonstrates superior consistency and survival rates compared to traditional intratracheal instillation and effectively validates the antifibrotic efficacy of nintedanib.
This study employs a novel coupled state-space inference (CSSI) framework to computationally demonstrate that the stability of reversed uridine-tetrad RNA G-quadruplex caps is encoded by a cooperative mechanism involving backbone reversal, cap–core stacking, and terminal cation organization, yielding calibrated predictions that support a falsifiable clamp–stack–ion energetic model.
This study of highly trained male collegiate soccer players reveals that faster reaction times, better selective response control (Go/No Go), and quicker target acquisition are the most critical sports visual abilities associated with superior short-passing performance, collectively explaining 76% of the variance in test results.
This study reveals that SENP7 plays a dual role in gene regulation, where its catalytic isopeptidase activity is sufficient to maintain developmental gene expression and chromatin compaction, while its N-terminal region is uniquely required to stabilize the repressive state of chromosome X genes.
This study demonstrates that blocking oxytocin receptors in male zebra finches disrupts the coordinated activity across social brain regions, thereby altering specific features of their context-sensitive song when singing to females.
This study integrates DIA proteomics and histopathology to reveal that pediatric coarctation of the aorta involves a coordinated yet directionally heterogeneous extracellular matrix remodeling profile, characterized by reduced structural collagen abundance alongside increased collagen maturation and elastic fiber remodeling proteins.
This paper characterizes the conditions under which representation-invariant quantum extensions of symmetric games can improve equilibrium payoffs, demonstrating that while classical-type and restricted quantum extensions often fail to provide strict mutual benefits, a specific genuinely quantum extension consistently supports non-inferior equilibria and yields strict improvements across all canonical payoff structures.