🧬 biology

Proteomic profiling of aortic wall remodeling in pediatric coarctation of the aorta: an integrative DIA proteomics and histopathology study

This study integrates DIA proteomics and histopathology to reveal that pediatric coarctation of the aorta involves a coordinated yet directionally heterogeneous extracellular matrix remodeling profile, characterized by reduced structural collagen abundance alongside increased collagen maturation and elastic fiber remodeling proteins.

Wei Cheng, Lulu Jia, Xipeng Wang, Jing Wei, Jinrui Zhang, Jiale Guo, Zhiqiang Li2026-08-06
🧬 biology

Nash Equilibrium Improvement in Quantum Extensions of Symmetric Games

This paper characterizes the conditions under which representation-invariant quantum extensions of symmetric 2×22 \times 2 games can improve equilibrium payoffs, demonstrating that while classical-type and restricted quantum extensions often fail to provide strict mutual benefits, a specific genuinely quantum extension consistently supports non-inferior equilibria and yields strict improvements across all canonical payoff structures.

Anna Gorczyca-Goraj, Krzysztof Grzanka, Piotr Frąckiewicz, Remigiusz Smoliński, Marek Szopa2026-08-06
🧬 biology

Association of habitual bathtub bathing with thermoregulatory responses in young men during hot- water immersion

This study demonstrates that habitual frequent bathtub bathing in young Japanese men is associated with significantly enhanced peripheral thermoregulatory responses, such as increased sweat rate and skin blood flow, suggesting that regular hot-water immersion may act as a form of passive heat acclimation.

Takayuki Nishimura, Akihiro Nakabayashi, Rinka Miura, Koji Soga, Takashi Ito, Kazuhiko Arima2026-08-06
🧬 biology

Evaluate the performance of Targeted Sequencing for Tumor FFPE Samples and ctDNA Standards on the Sikun 2000

This study demonstrates that the Sikun 2000 sequencing platform delivers superior quality metrics, high reproducibility, and enhanced sensitivity for detecting low-frequency variants in tumor FFPE samples and ctDNA standards compared to established Illumina platforms, establishing it as a competitive alternative for clinical and research applications.

Jiuzhou Zhao, Tianbo Wang, Li Zhao, Jiawen Zheng, Chengzhi Zhao, Junnan Feng, Rui Sun, Chengjiao Duan, Dongdong Chen, Ke (…)2026-08-06
🧬 biology

Sex Differences in the Brain Transcriptome and the GnRH/GnRHR Gene Family of Siniperca scherzeri

This study elucidates the molecular basis of sexual growth dimorphism in *Siniperca scherzeri* by identifying brain-specific, male-biased expression of GnRH ligands that link reproductive and growth axes to drive differential energy allocation between sexes.

Zihang Xie, Shengyue Lin, Weijian Chen, Guojun Cai, Ziyan Deng, Zixuan He, Jiayu Li, Shanghong Chen, Jieying Chen, Chong (…)2026-08-06
🧬 biology

Molecular characterisation of an Italian cohort of Silver-Russell Syndrome patients by -omics approaches

This study characterizes the molecular heterogeneity of an Italian Silver-Russell Syndrome cohort using integrated -omics approaches, identifying a significant proportion of cases with non-canonical genetic and epigenetic defects and supporting a shift toward a molecular rather than clinical diagnosis.

Flavia Cerrato, Emilia D’Angelo, Laura Pignata, Abu Saadat, Francesco Cecere, Aurora Esposito, Federica Rossetti, Carlo (…)2026-08-06