4226 papers
This study identifies ETV1 as a critical mediator that couples reciprocal FGF23 and PTH signaling to regulate renal CYP24A1 expression, thereby governing endocrine mineral homeostasis through dynamic interactions with VDR and COP1.
This study demonstrates that habitual frequent bathtub bathing in young Japanese men is associated with significantly enhanced peripheral thermoregulatory responses, such as increased sweat rate and skin blood flow, suggesting that regular hot-water immersion may act as a form of passive heat acclimation.
This study demonstrates that the Sikun 2000 sequencing platform delivers superior quality metrics, high reproducibility, and enhanced sensitivity for detecting low-frequency variants in tumor FFPE samples and ctDNA standards compared to established Illumina platforms, establishing it as a competitive alternative for clinical and research applications.
This study demonstrates that the growth advantage of high spatial learning ability in crucian carp is contingent upon environmental predictability, as it only manifests in dynamic environments where it is supported by a tightly integrated physiological phenotype coordinating stress, growth, and neural axes.
This study identifies a novel c-Cbl-mediated non-canonical neddylation pathway that stabilizes TGFBR2 to drive TGF-β signaling and metastasis in BRAF V600E melanoma, highlighting this post-translational modification axis as a promising therapeutic target.
This study elucidates the molecular basis of sexual growth dimorphism in *Siniperca scherzeri* by identifying brain-specific, male-biased expression of GnRH ligands that link reproductive and growth axes to drive differential energy allocation between sexes.
This study characterizes the molecular heterogeneity of an Italian Silver-Russell Syndrome cohort using integrated -omics approaches, identifying a significant proportion of cases with non-canonical genetic and epigenetic defects and supporting a shift toward a molecular rather than clinical diagnosis.
This study presents HyGD-Net, an explainable deep learning framework that achieves accurate, nondestructive authentication of *Pinellia ternata* against its toxic adulterant *P. pedatisecta* across tuber, slice, and powder forms using hyperspectral imaging, with its spectral feature attribution chemically corroborated by GC–TOF–MS profiling.
This study demonstrates that pre-operative habituation and post-operative housing conditions interact to shape both the magnitude and, more significantly, the inter-individual consistency of physiological recovery following kidney imaging window implantation in mice, with effects varying by sex.
This study integrates genetic analyses and biophysical modeling to reveal that gooseneck barnacle populations in the north-east Atlantic are separated by the Strait of Gibraltar but exhibit a complex connectivity pattern within Europe, characterized by post-glacial recolonization from an Iberian refuge and a metapopulation dynamic in Brittany sustained by occasional long-distance larval dispersal.