4244 papers
The paper introduces RECIPE, a graph neural network framework that leverages Ribo-seq or transcriptomic data integrated with protein-protein interaction networks to accurately predict proteome-wide protein abundances, effectively overcoming the limitations of incomplete proteomics measurements in both bulk and single-cell settings.
The study introduces the MiNi-PD framework to prioritize gut-brain axes in Parkinson's disease, revealing that short-chain fatty acid-linked metabolites, particularly butyrate and 3-indolepropionic acid, converge on the host gene IL1B within the substantia nigra to define a biologically meaningful inflammatory mechanism.
This study elucidates the mechanistic versatility of the mycobacterial MsSpns transporter by demonstrating how protonation-driven conformational changes and distinct substrate interactions enable the Spns fold to power opposing transport modes, facilitating both the efflux of hydrophilic cations and the uptake of lipophilic compounds.
The paper introduces Fuji, a multimodal pathology foundation model trained on over 60,000 whole-slide images paired with genomic data that successfully infers genome-scale molecular states, mutational processes, and clinical outcomes directly from routine histology, thereby bridging the gap between tissue morphology and underlying molecular mechanisms.
This study reveals that clear cell renal cell carcinoma is characterized by a significant reduction and oxidative remodeling of cardiolipin, reflecting mitochondrial depletion and an insufficient compensatory upregulation of the remodeling enzyme TAZ, which collectively highlight a potential metabolic vulnerability in the disease.
This study introduces MIDLPred, an ensemble learning framework utilizing a one-dimensional convolutional neural network to accurately classify male infertility candidate proteins into four distinct phenotype categories directly from their primary amino acid sequences, thereby aiding researchers in prioritizing targets for further investigation.
This study reports the first records of two soft coral species, *Cladiella pachyclados* and *Aldersladum sodwanum*, from the Gulf of Kachchh, India, using combined morphological and molecular data to provide provisional identifications while highlighting the need for further integrative taxonomic work to resolve phylogenetic ambiguities and support conservation efforts in this extreme reef ecosystem.
This study demonstrates that the initial cell number in soil micro-aggregates is a critical driver of microbial community assembly, regulating biofilm formation, taxonomic dominance, diversity, and association networks in a carbon-source-dependent manner.
This study demonstrates that directional autonomic coupling, particularly sympathetic coupling from leader to follower, can distinguish socially mediated transmission from common-input synchrony, revealing that interpersonal physiological alignment is channel- and context-dependent.
This study identifies 98 neuromelanin-binding plasma proteins through affinity chromatography and bioinformatics, revealing their enrichment in inflammation, vascular, and amyloid-related pathways to suggest that peripheral interactions with neuromelanin may serve as a proxy for understanding neurodegenerative mechanisms and developing early diagnostic strategies.