4244 papers
This paper introduces a naturalistic database comprising 22 movie clips and associated emotional ratings from 108 healthy adults, designed to facilitate the study of individual differences in affective responses by analyzing dynamic, integrative, and normative features of emotional reactivity alongside biological and stimulus variables.
This study reveals that C57Bl6 mice undergo a critical, organ-specific transcriptional and metabolic maturation between 8 and 12 weeks of age, characterized by a heart shift toward maintenance, kidney immune activation, and liver lipid metabolism dominance, all driven by a coordinated gut-liver axis transition that establishes a stable, energy-efficient adult phenotype.
This study demonstrates that NMN-responsive transcriptional programs, particularly those involving CPT2-linked fatty acid oxidation and specific autophagy nodes, significantly overlap with the genetic liability of schizophrenia and treatment-resistant schizophrenia, suggesting new metabolic and cellular homeostasis targets for therapeutic intervention beyond traditional receptor-centered models.
This study presents longitudinal plasma proteome data from a critically ill Ebola virus disease survivor treated with a placebo, revealing that a broad reduction in plasma proteins coincided with the cessation of viral replication and providing detailed insights into the dysregulated coagulation and innate immune pathways that persist during recovery to inform future host-directed therapies.
NeuroSparkSNT is an eight-operator framework built on the C. elegans connectome that utilizes a semi-Markov phase controller to structurally enforce mutually exclusive behavioral states, successfully reproducing experimental locomotion dynamics and generating falsifiable predictions while offering a pathway toward a homeostatically regulated foraging agent without external reward functions.
This study demonstrates that school-aged children (5–17 years) can effectively utilize haptic communication through a robotic interface to improve motor performance in cooperative tasks, with their ability to exploit these cues and benefit from skilled partners increasing with age.
This study employs integrated multi-omics analysis to characterize the immune microenvironment remodeling in metastatic castrate-resistant prostate cancer (mCRPC), identifying BRAF as a key upregulated regulator and highlighting the pivotal roles of tumor-associated macrophages and natural killer T cells in disease progression.
This study demonstrates that endophytic strains *Talaromyces verruculosus* (FBL-5) and *Stenotrophomonas maltophilia* (BBL-13), isolated from the medicinal plant *Berberis aristata*, exhibit significant antimicrobial activity and produce the bioactive compound berberine, highlighting their potential as sustainable sources for pharmaceutical development and plant conservation.
This study identifies a novel ~21 kDa porphyrin-binding protein (Fq PBP) from *Flavobacterium quisquiliarum* that independently disrupts *Pseudomonas aeruginosa* biofilms through porphyrin sequestration and iron homeostasis interference, offering a potential therapeutic strategy against chronic infections.
This study demonstrates that replacing native phylloquinones with plastoquinone-9 in the *menB* variants of *Synechocystis* sp. PCC 6803 drastically slows forward electron transfer and thermodynamically favors electron flow through the B-branch over the A-branch of Photosystem I.