4244 papers
Low-frequency electroacupuncture activates mTORC1 signaling in mouse tibialis anterior muscle regardless of the time of day, yet this activation does not immediately increase global protein synthesis, suggesting it may instead prime the muscle for future anabolic responses.
By analyzing 7.4 million camera-trap days across 199 Chinese nature reserves, this study reveals that protected areas suffer from pervasive, non-random "dark diversity" deficits—missing over half of their expected mammal species and significant evolutionary and functional traits—demonstrating that traditional species richness assessments severely underestimate biodiversity erosion and highlighting the need for multidimensional frameworks to guide conservation recovery.
This study systematically characterizes the morphological diversity of amyloid-beta plaques across 23 brain regions in Alzheimer's disease, revealing distinct regional distributions and unique clinicopathological associations for specific plaque subtypes, particularly highlighting that cored plaques and cerebral amyloid angiopathy exhibit statistically distinct patterns compared to other deposit classes.
This study successfully purified and characterized alkaline phosphatase from *Phaseolus vulgaris* (cranberry group) seeds using a dual strategy of low-temperature ultracentrifugation and anion-exchange FPLC, achieving significant enrichment with high recovery, optimal activity at pH 10.0 and 40°C, and a molecular weight of approximately 63–70 kDa.
This study applies a uniform genome-mining workflow to a panel of 100 *Streptomyces* assemblies, revealing that over half of the predicted biosynthetic gene clusters exhibit low similarity to known references, thereby generating a reproducible, sequence-based resource for prioritizing novel biosynthetic potential in *S. clavuligerus* and related species.
This study utilizes spatial transcriptomic analysis of over one million cortical locations from 64 human donors to provide evidence that Amyotrophic Lateral Sclerosis (ALS) involves the aberrant reactivation of an embryonic Arp2/3–actomyosin developmental gene program.
Despite sharing similar dietary specializations, bats, carnivorans, and primates evolved distinct mandibular shapes and adaptive zones driven primarily by their unique phylogenetic histories rather than convergent ecological pressures.
This study demonstrates that the *ZaTPS* gene in *Zanthoxylum armatum* confers rust resistance by upregulating linalool biosynthesis and enhancing the antioxidant defense system, thereby offering a valuable genetic resource for breeding resistant cultivars.
This study demonstrates that the long noncoding RNA H19 prevents cellular senescence by suppressing p21 expression through two distinct mechanisms: recruiting the Wig1-Upf1 complex to induce mRNA decay and sponging eIF3 to inhibit translation initiation.
This study elucidates how mosquito species, virus dose, and viral stock origin differentially influence the stage-specific vector competence and infection dynamics of *Aedes aegypti* and *Culex quinquefasciatus* for Rift Valley Fever Virus, providing a standardized reference dataset and modeling framework to better understand and predict RVFV emergence.