4244 papers
This study demonstrates that O-GalNAc glycosylation, mediated by GalNT3, restores the intestinal mucosal barrier damaged by lipopolysaccharides by repairing MUC2 structure and maintaining E-cadherin-mediated cell adhesion through the regulation of calcium homeostasis.
This paper presents a combined approach using chronically implanted ultra-flexible electrodes and two-photon calcium imaging to simultaneously record subcortical and cortical neural activity in mice, enabling the investigation of brain-wide dynamics across slow brain states and fast ripple events.
This study reveals that cryptobenthic fish assemblages in the Aegean Sea are primarily structured by depth and habitat type, with specific species serving as bay-dependent indicators for Mediterranean coastal habitats despite a lack of significant differences in diversity metrics or protection status.
This study demonstrates that *Cytobacillus horneckiae* S1 effectively degrades phenanthrene through upregulated meta-cleavage pathway enzymes, as confirmed by genomic identification of thirty relevant genes and growth experiments, highlighting its potential for marine bioremediation.
This study demonstrates that downregulation of DLC1 in hepatocellular carcinoma is associated with malignant phenotypes and enriched fibroblast-stellate matrix programs characterized by extracellular matrix and integrin signaling, without establishing a direct causal mechanism for stromal remodeling.
This study demonstrates that the secretome derived from hypoxia-preconditioned human dental pulp mesenchymal stem cells significantly accelerates wound healing and tissue regeneration in a medicinal leech model by modulating conserved mechanisms of extracellular matrix remodeling and angiogenesis, thereby supporting its potential as a therapeutic strategy for chronic human wounds.
This study demonstrates that 18 months after vaccination in Pakistan, a population with limited booster access maintained robust humoral, cellular, and transcriptional immune signatures against SARS-CoV-2, suggesting that hybrid immunity from vaccination and natural infection provided durable protection with low morbidity and mortality.
Chronic ethanol exposure leads to the sex-specific downregulation of the NRXN3β transcript and its postsynaptic binding partners in the prefrontal cortex across rhesus macaques and mice, suggesting a disruption of synaptic plasticity in parvalbumin interneurons and excitatory neurons.
This paper proposes a foundational framework called Meaning–Experience Coupling (MEC), which defines semantic information as an emergent property of the structural alignment between representational organization and agentive goals, formalized through a coherence functional that satisfies five specific axioms to explain how information becomes meaningful for experiencing and acting systems.
This study reveals that tanycytes regulate hypothalamic thermoregulation by releasing nutrient-dependent Annexin A1 via extracellular vesicles to modulate microglial activity, thereby establishing a critical metabolic-immune axis where disrupted signaling leads to microglial activation and hyperthermia.